| Gene Symbol | LRRK2 |
| Full Name | R1441C Dopaminergic Neurons |
| Chromosome | 12q12 |
| Protein Type | Protein |
| Amino Acids | 2527 aa |
| Pathways | MAPK |
| UniProt ID | Search UniProt |
| GeneCards | LRRK2 |
| Human Protein Atlas | LRRK2 |
| LRRK2 | Leucine-rich repeat kinase 2 protein |
| Parkinson's Disease | Primary clinical manifestation |
| Substantia Nigra Pars Compacta | Anatomical location of vulnerable neurons |
| RAB GTPases | Downstream LRRK2 effectors |
| Autophagy-Lysosomal Pathway | Impaired cellular process |
| α-Synuclein | Accumulating pathological protein |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | BIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa |
| Interactions | 6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT |
| SciDEX Hypotheses | G2019S primarily raises baseline LRRK2 kinase acti Therapeutic Window Exists Because Amplified Signal LRRK2 Volume Sensor Hijacking Drives Metabolic Dys (+2 more) |
| KG Connections | 2616 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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