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cell 1,280 words KG: ent-gene-9f063e98
Contents

LRRK2-Associated Dopamine Neurons

🔬 Protein Info
Gene SymbolLRRK2
Full NameAssociated Dopamine Neurons
Chromosome12q12
Protein TypeProtein
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsBIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa
Interactions6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT
SciDEX HypothesesG2019S primarily raises baseline LRRK2 kinase acti
Therapeutic Window Exists Because Amplified Signal
LRRK2 Volume Sensor Hijacking Drives Metabolic Dys (+2 more)
KG Connections2614 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (9)

Senescent Cell Mitochondrial DNA Release
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38...
Score: 0.68Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61

Related Analyses (12)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (23)

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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