cell 594 words KG: ent-gene-83d99ff1
Contents

FUS-Mutant Motor Neurons

🔬 Protein Info
Gene SymbolFUS
Full NameMutant Motor Neurons
Chromosome16p11.2.
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDSearch UniProt
GeneCardsFUS
Human Protein AtlasFUS
Morphologymotor neuron (source: Cell Ontology)
RNA ProcessingSplicing and transport
DNA RepairHomologous recombination
Associated DiseasesAD, Aging, ALI, Als, ALS/FTD
Known Drugs/CompoundsADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides
InteractionsACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
Arginine Methylation Loss on FUS RGG Domains Drive
RNA-binding protein condensate maturation from rev (+5 more)
KG Connections1549 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (6)

Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (12)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived

Related Experiments (3)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

h-0c9e2166ed targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-0c9e2166ed
h-297a9dcbfa targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-297a9dcbfa
h-a23cc3c8b9 targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-a23cc3c8b9
h-4c4bf4a28f targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-4c4bf4a28f
ent-gene-83d99ff1 participates_in_pathway R-HSA-72163
ent-gene-83d99ff1 participates_in_pathway R-HSA-72203

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