Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange

graph TD
    A["PANX1 Gene
Expression"]
    B["Pannexin-1
Hemichannel
Formation"]
    C["ATP Depletion
in Neuronal
Cells"]
    D["Hemichannel
Opening
Triggers"]
    E["Mitochondrial
Component
Release"]
    F["Intercellular
Transfer via
Hemichannels"]
    G["Healthy Donor
Cell Mitochondria"]
    H["Compromised
Recipient Cell
Mitochondria"]
    I["Mitochondrial
Function
Restoration"]
    J["ATP Production
Recovery"]
    K["Oxidative Stress
Reduction"]
    L["Neuronal
Survival"]
    M["Pharmacological
Hemichannel
Modulators"]
    N["Controlled
Channel
Permeability"]
    O["Neurodegeneration
Prevention"]

    A -->|"transcription and
translation"| B
    C -->|"cellular stress
signals"| D
    D -->|"mechanical or
chemical stimulus"| B
    B -->|"pore formation"| N
    G -->|"donor cell
mitochondrial export"| E
    E -->|"molecular transport"| F
    F -->|"uptake by
recipient cell"| H
    H -->|"functional
integration"| I
    I -->|"restored
bioenergetics"| J
    I -->|"antioxidant
capacity"| K
    J -->|"cellular
energy supply"| L
    K -->|"reduced
damage"| L
    L -->|"neuroprotection"| O
    M -->|"therapeutic
intervention"| N
    N -->|"optimized
transport"| F

    classDef normal fill:#4fc3f7
    classDef therapeutic fill:#81c784
    classDef pathological fill:#ef5350
    classDef outcome fill:#ffd54f
    classDef molecular fill:#ce93d8

    class A,B,E,F,G,I molecular
    class J,K,L normal
    class M,N therapeutic
    class C,H pathological
    class O outcome