Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about abcbl: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABCB1 |
| Full Name | ATP-Binding Cassette Subfamily B Member 1 |
| Chromosome | 7q21.12 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | encodes a 170 kDa ATP-dependent efflux transporter that is a critical component of the blood-brain barrier. |
| Mechanism of Action | Small molecule inhibitors to reduce efflux pump activity and enhance CNS drug penetration |
| Primary Expression | the cortex and hippocampus, with moderate levels in the cerebellum and brainstem |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase III |
| Molecular Weight | 170 kDa |
| Exons | 29 |
| Pathways | Apoptosis, Blood-Brain Barrier, Ferroptosis, Nf-Κb, Notch |
| Ensembl ID | ENSG00000085563 |
| GeneCards | ABCB1 |
| Human Protein Atlas | ABCB1 |
| Associated Diseases | AD, Aging, Als, Alzheimer |
| Known Drugs/Compounds | Tariquidar, Elacridar |
| Interactions | ABCG2, ACOX1, Actin, AKT, APOD, APOPTOSIS |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 587 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["abcbl gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ABCBL | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ABCBL | data_in | dataset_row | 0.00 |
| genes-abcbl | describes | wiki_page | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning abcbl in their description or question text
No additional research found