concept

V-ATPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about V-ATPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

2Hypotheses

3Analyses

14Outgoing

16Incoming

0Experiments

3Debates

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💡 Concept Info

Name	V-ATPASE
Key Genes/Proteins	ATG16L1, MAPT, RAB7, SOPF, VGLUT1

Pathway Diagram

graph TD
    V_ATPASE["V-ATPASE"]
    V_ATPASE -->|"regulates"| LC3_Associated_Phagocytosis["LC3-Associated Phagocytosis"]
    V_ATPASE -->|"regulates"| Rab7["Rab7"]
    V_ATPASE -->|"regulates"| Late_Endosomal_Ph["Late Endosomal Ph"]
    V_ATPASE -->|"interacts"| ATG16L1["ATG16L1"]
    V_ATPASE -->|"activates"| Casm["Casm"]
    V_ATPASE -->|"activates"| xenophagy["xenophagy"]
    V_ATPASE -->|"activates"| Rab7a["Rab7a"]
    SOPF["SOPF"] -->|"inhibits"| V_ATPASE
    ATP6V1G1["ATP6V1G1"] -->|"expressed in"| V_ATPASE
    VGLUT1["VGLUT1"] -->|"depends_on"| V_ATPASE
    ATG16L1_WD40_domain["ATG16L1 WD40 domain"] -->|"interacts"| V_ATPASE
    Rab7 -->|"interacts"| V_ATPASE
    NADPH_oxidase["NADPH oxidase"] -->|"interacts"| V_ATPASE
    Salmonella_SopF["Salmonella SopF"] -->|"inhibits"| V_ATPASE
    TMEM55B["TMEM55B"] -->|"contributes to"| V_ATPASE

Outgoing (14)

Target	Relation	Type	Str
Late Endosomal Ph	regulates	process	0.95
LC3-Associated Phagocytosis	regulates	process	0.95
Rab7	regulates	protein	0.95
LC3-associated phagocytosis	regulates	process	0.95
ATG16L1	interacts_with	protein	0.93
ATG16L1	interacts_with	protein	0.93
Casm	activates	process	0.92
xenophagy	activates	pathway	0.90
RAB7	activates	protein	0.90
Rab7a	activates	protein	0.90
RAB7A	modulates	protein	0.90
endosomal-lysosomal trafficking	involved_in	process	0.90
lysosomal pH	regulates	phenotype	0.85
lysosomal pH	modulates	mechanism	0.70

Incoming (16)

Source	Relation	Type	Str
SLC45A1	interacts_with	protein	0.90
ATP6V1A	encodes_subunit_of	gene	0.90
MAPT	binds	gene	0.90
ATP6V1G1	associated_with	gene	0.90
SOPF	inhibits	protein	0.88
VGLUT1	depends_on	protein	0.85
ATP6V1G1	expressed_in	gene	0.85
ATG16L1 WD40 domain	interacts_with	protein	0.80
Rab7	interacts_with	protein	0.80
endosomal maturation	associated_with	process	0.80
Slc45A1	interacts_with	protein	0.80
Salmonella SopF	inhibits	protein	0.70
NADPH oxidase	interacts_with	protein	0.70
Aβ42	binds	protein	0.70
TMEM55B	contributes_to	protein	0.70
TFEB	transcription_factor_regulates	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Restoration of V-ATPase function reverses lysosomal acidific	0.630	neuroscience	Lysosomal dysfunction and cathepsin leak
Lysosomal Accumulation-Induced V-ATPase Inhibition (Osmotic	0.470	neurodegeneration	Why do structurally diverse sugars (treh