| Gene Symbol | TIM23 |
| Aliases | TIM23 complex |
| Function | Given the central role of mitochondria in neuronal function—particularly in high-energy demanding dopaminergic neurons and other neuronal subtypes—TIM23-mediated protein import is fundamental to ne... |
| Subcellular Localization | inner mitochondrial membrane |
| Molecular Weight | 16 kDa |
| Pathways | mitophagy |
| GeneCards | TIM23 |
| Human Protein Atlas | TIM23 |
| Transmembrane domain (residues ~50-70) | Single α-helical transmembrane segment that anchors TIM23 in the inner mitochondrial membrane |
| N-terminal region (residues 1-50) | Faces the intermembrane space (IMS), contains substrate-binding sites |
| C-terminal region (residues 70-150) | Faces the matrix, contains interaction domains |
| Lateral gate | Allows substrate release into the lipid phase of the membrane |
| Tim17 | Most similar, also small IMS-facing subunit |
| Tim22 | Central transport channel |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Interactions | HSP60, NDP52, OPTINEURIN, PINK1 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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