gene

TAB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

6Outgoing

9Incoming

0Experiments

0Debates

Summary

TAB2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Huntington, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TAB2
Aliases	TAK1-Binding Protein 2
Chromosome	6p25.1
Protein Family	TAK1-binding proteins
Protein Type	Adaptor Protein
Function	TAB2 is an adaptor protein that links TAK1 to TRAF6 in the NF-κB activation pathway.
Primary Expression	neurons and glial cells, where it regulates inflammatory responses
Molecular Weight	77.8 kDa
Amino Acids	693 aa
Pathways	cascade: ### TAK1 Activation Complex, NF-κB, MAPK, MAPK pathway, MAPK signaling
UniProt ID	[Q9Y2K2](https://www.uniprot.org/uniprot/Q9Y2K2)
GeneCards	TAB2
Human Protein Atlas	TAB2
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, HUNTINGTON, HUNTINGTON'S DISEASE, JNK, MICRORNAS, MIRNAS
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAB2["TAB2"]
    Huntington{"Huntington"}
    TAB2 -->|"activates"| Huntington
    Neurodegeneration{"Neurodegeneration"}
    TAB2 -->|"activates"| Neurodegeneration
    Als{"Als"}
    TAB2 -->|"activates"| Als
    Apoptosis["Apoptosis"]
    TAB2 -->|"activates"| Apoptosis
    Stem_Cell["Stem Cell"]
    TAB2 -->|"activates"| Stem_Cell
    Microrna["Microrna"]
    TAB2 -->|"activates"| Microrna
    MIRNAS(["MIRNAS"])
    MIRNAS -->|"activates"| TAB2
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"activates"| TAB2
    HUNTINGTON(["HUNTINGTON"])
    HUNTINGTON -->|"activates"| TAB2
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATION -->|"activates"| TAB2
    style TAB2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (6)

Target	Relation	Type	Str
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Microrna	activates	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
proteins-tab2	describes	wiki	1.00
MIRNAS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICRORNAS	activates	gene	0.60
HUNTINGTON'S DISEASE	activates	gene	0.60
TAK1	activates	gene	0.60
JNK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAB2 in their description or question text

No additional research found