Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic function / plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Mediated Cholinergic Synapse Disruption | 0.763 | neurodegeneration | Senolytic therapy for age-related neurod |
| Sleep Spindle-Synaptic Plasticity Enhancement | 0.721 | neurodegeneration | Sleep disruption as cause and consequenc |
| Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass | 0.683 | neurodevelopment | How does SYNGAP1, a 'synaptic' protein, |
| Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics | 0.625 | neurodegeneration | Synaptic pruning by microglia in early A |
| Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto | 0.620 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| Trans-Synaptic Adhesion Molecule Modulation | 0.544 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.782
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Spp1 knockout prevents synaptic loss in AD mouse models | validation | Alzheimer's disease | 0.900 | 0.00 | Spp1 knockout AD mouse models | proposed | N/A |
| Adoptive transfer of TCRAβ-Tregs in AD mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | transgenic mice expressing chi | proposed | N/A |
| AhR transcriptional regulation of NEP gene | exploratory | Alzheimer's disease | 0.850 | 0.00 | Cell culture system | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep Disruption and Alzheimer's Disease — mechanism and intervention | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Synaptic Vesicle Trafficking Dysfunction Validation in Parkinson's Dis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune mi [PMID:39237260] | Hou Z, Lu F, Lin J, Wu Y, Chen L, Fang H | J Immunother Cancer | 2024 | 1 |
| The role of annexins in central nervous system development and disease. [PMID:38639785] | White ZB 2nd, Nair S, Bredel M | J Mol Med (Berl) | 2024 | 1 |
| Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury vi [PMID:37908731] | Zhou H, Yan L, Huang H, Li X, Xia Q, Zhe | Theranostics | 2023 | 1 |
| Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating m [PMID:34022892] | Xu X, Gao W, Li L, Hao J, Yang B, Wang T | J Neuroinflammation | 2021 | 1 |
| Annexin A1: Uncovering the Many Talents of an Old Protein. [PMID:29614751] | Sheikh MH, Solito E | Int J Mol Sci | 2018 | 1 |
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| LINC00491 promotes nasopharyngeal carcinoma metastasis by binding to purine-rich [PMID:41903631] | ["Liu Y", "Li H", "Zhang J", "Peng J", " | International journal of biolo | 2026 | 0 |
| GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activi [PMID:41693050] | ["Tiliwaerde M", "Zhaoji D", "Jingjing L | British journal of pharmacolog | 2026 | 0 |
| CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970] | Lu W, Kawatani K, Ren Y | Alzheimers Res Ther | 2026 | 0 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536] | Zheng ZW, Min PX, Luo YL, Mao XF, Zhang | Neuron | 2026 | 0 |
| Annexin A1 enhances liver repair after acetaminophen-induced liver injury by reg [PMID:41707743] | ["Zha L", "Liu D", "Zhan M", "Xu Y", "Ha | Free radical biology & medicin | 2026 | 0 |
| Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac inj [PMID:41695468] | ["Nayak T", "Bajpai A", "Patwa V", "Cart | Theranostics | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autono [PMID:41723507] | ["Duque V", "Nani J", "Jovanovic M", "Lo | Biology of sex differences | 2026 | 0 |
| Attenuated crosstalk between urothelium and fibroblasts promotes ureteral strict [PMID:41924262] | ["Guo R", "Zhang X", "Wang C", "Cui J", | Frontiers in immunology | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning Synaptic function / plasticity in their description or question text