| Gene Symbol | SPG15 |
| Full Name | SPG15 - Spastic Paraplegia 15 |
| Aliases | SPG15PROTEIN |
| Chromosome | 14q24.3. |
| Protein Type | Gene |
| Function | is a hereditary neurological disorder classified as a complex form of hereditary spastic paraplegia (HSP) characterized by progressive lower limb spasticity and weakness. |
| Subcellular Localization | </strong></td><td>Cytoplasm, endosomes, autophagosomes, lysosomes</td></tr> |
| Molecular Weight | 209 kDa |
| Amino Acids | 897 aa |
| Exons | 47 |
| GeneCards | SPG15 |
| Human Protein Atlas | SPG15 |
| FYVE domain | Conserved 60-80 amino acid zinc finger that binds specifically to phosphatidylinositol 3-phosphate (PI3P) on endosomal membranes |
| Coiled-coil regions | Enable homodimerization and interaction with other autophagy proteins |
| Multiple phosphorylation sites | Regulate protein function through post-translational modification |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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