Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMAD3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SMAD Family Member 3 is a SMAD family member. The protein contains the characteristic domain structure including domain descriptions. The molecular weight is approximately 48 kDa, and the protein localizes to Cytoplasm, nucleus.
No AI portrait yet
| Gene Symbol | SMAD3PROTEIN |
| Chromosome | 15q22 |
| Protein Type | Receptor |
| Function | SMAD Family Member 3 is a SMAD family member. The protein contains the characteristic domain structure including domain descriptions. The molecular weight is approximately 48 kDa, and the protein loca |
| Subcellular Localization | ** | Cytoplasm, nucleus | |
| Molecular Weight | 48 kDa |
| GeneCards | SMAD3PROTEIN |
| Human Protein Atlas | SMAD3PROTEIN |
| Associated Diseases | Aging, Als, Alzheimer, Crohn'S Disease, Diabetes |
| Known Drugs/Compounds | lycopene |
| Interactions | ABCG2, ACTB, adamts4, ADAMTS4, AGING, AKT |
| KG Connections | 370 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SMAD3PROTEIN["SMAD3PROTEIN"]
neurodegeneration["neurodegeneration"]
SMAD3PROTEIN -->|"implicated_in"| neurodegeneration
style SMAD3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SMAD3PROTEIN in their description or question text
No additional research found