gene

ROBO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROBO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

4Outgoing

2Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ROBO2
Chromosome	3p12.3
Protein Type	Gene
Function	ROBO2 (Roundabout Guidance Receptor 2) is a transmembrane receptor for Slit proteins (Slit1, Slit2, Slit3) that plays critical roles in axon guidance, neuronal migration, and neural crest cell migrati
Primary Expression	developing midbrain dopaminergic neurons and regulates their proper migration and axonal projection [@jaworski2019]
Pathways	MAPK, PI3K
GeneCards	ROBO2
Human Protein Atlas	ROBO2
Extracellular Domain	5 immunoglobulin (Ig) domains followed by 3 fibronectin type III (FNIII) repeats, mediating ligand binding
Transmembrane Domain	Single pass membrane-spanning helix
Cytoplasmic Domain	Contains conserved motifs including CC0, CC1, and CC2 (conserved cytoplasmic motifs) that recruit downstream signaling proteins
Rho GTPase-activating proteins (GAPs)	Regulate RhoA, Rac1, and Cdc42 activity
Disabled-1 (Dab1)	Adapter protein involved in cytoskeletal reorganization
RhoGEFs	Activate specific Rho GTPases for cytoskeletal remodeling
Midline repulsion	Prevents inappropriate crossing of the midline in the central nervous system
Associated Diseases	Schizophrenia
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ROBO2 Gene

gene · 1494 words

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Pathway Diagram

flowchart TD
    ROBO2(["ROBO2"])
    Schizophrenia["Schizophrenia"]
    Neuron["Neuron"]
    Stem_Cell["Stem Cell"]
    FOXP2(["FOXP2"])
    AXON(["AXON"])
    Thalamus["Thalamus"]
    neurodegeneration["neurodegeneration"]

    ROBO2 -->|"associated with"| Schizophrenia
    ROBO2 -->|"associated with"| Neuron
    ROBO2 -->|"associated with"| Stem_Cell
    FOXP2 -->|"regulates"| ROBO2
    AXON -->|"regulates"| ROBO2
    ROBO2 -->|"expressed in"| Thalamus
    ROBO2 -->|"implicated in"| neurodegeneration

    style ROBO2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Schizophrenia	associated_with	disease	0.65
Neuron	associated_with	cell_type	0.60
Stem Cell	associated_with	cell_type	0.60
Thalamus	expressed_in	brain_region	0.55

Incoming (2)

Source	Relation	Type	Str
AXON	regulates	gene	0.60
FOXP2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ROBO2 in their description or question text

No additional research found