Protein

The abstract mentions that pathological seeds have different characteristics and

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Protein aggregation cross-seeding across neurodegenerative diseases?

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

How do host cell factors influence the conformation and propagation properties o

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

While the abstract establishes that intercellular transmission occurs for variou

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Analysis question not specified

closed · Rounds: 4 · Score: 0.53 · 2026-04-06

Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Blood as an Early Indi

Score: 0.640 · unknown disease · 2026-04-26

Elevated MMP-9/TIMP-1 ratio reflects net proteolytic activity against the BBB, causing degradation of tight junction pro

J-protein co-chaperone repertoire enables selective recognition of pathogenic co

Score: 0.630 · protein biochemistry · 2026-04-21

**Molecular Mechanism and Rationale** The J-protein co-chaperone system represents a sophisticated cellular quality con

Pericyte senescence is sufficient to weaken the BBB even without classic amyloid

Score: 0.630 · neurodegeneration · 2026-04-25

Selective induction of a senescence program in adult pericytes is sufficient to impair barrier-supportive trophic signal

RNA-Binding Protein Sequestration and 3′UTR Dysregulation

Score: 0.625 · unknown disease · 2026-04-26

Intron-retained GBA isoform sequesters neuronal RBPs (FMRP, HuR, TDP-43) that normally bind to wild-type GBA mRNA 3′UTR

Heat Shock Protein 70 Disaggregase Amplification

Score: 0.625 · neurodegeneration · 2026-04-02

## Molecular Mechanism and Rationale The HSP70 chaperone system operates as a protein disaggregation machine through an

Serine/Arginine-Rich Protein Kinase Modulation

Score: 0.624 · neurodegeneration · 2026-04-02

## Mechanistic Overview Serine/Arginine-Rich Protein Kinase Modulation starts from the claim that modulating SRPK1 withi

Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial deliver

Score: 0.621 · neurodegeneration · 2026-04-02

## Mechanistic Overview Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial delivery starts from th

Tau fibrils expose neuronal phosphatidylserine and heat-shock protein 70, drivin

Score: 0.620 · neurodegeneration · 2026-04-22

## Mechanistic Overview Tau fibrils expose neuronal phosphatidylserine and heat-shock protein 70, driving microglial non

CSF ApoE- and clusterin-rich lipoprotein particles stabilize disease-relevant al

Score: 0.606 · neurodegeneration · 2026-04-25

Specific lipoprotein particles bind fibril surfaces and preserve polymorph architecture and seeding fidelity outside the

A genetically encoded reporter for axonal mitochondrial protein import fidelity

Score: 0.540 · neuroscience · 2026-04-26

MTS-dGFP fusion construct requires intact TOM40/TOM20 translocase for mitochondrial import, serving as direct read-out o

VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking

Score: 0.517 · proteomics · 2026-04-25

VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking

Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drives Early Tight Juncti

Score: 0.515 · unknown disease · 2026-04-26

Neuroinflammation triggers astrocyte and microglial MMP-9 activation, which proteolytically cleaves claudin-5, the princ

Circulating IBA1 Protein Absorption/Interference with Detection

Score: 0.507 · neuroinflammation · 2026-04-21

## Mechanistic Overview Circulating IBA1 Protein Absorption/Interference with Detection starts from the claim that modul

RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex

Score: 0.497 · molecular neurobiology · 2026-04-25

An auxiliary protein, such as TDP-43, FUS, or an hnRNP family member, may bind lncRNA-0021 and/or mmu-miR-6361 to increa

Conditional CRISPR Kill Switches for Aberrant Protein Clearance

Score: 0.496 · neurodegeneration · 2026-04-04

## Mechanistic Overview Conditional CRISPR Kill Switches for Aberrant Protein Clearance starts from the claim that modul