gene

PSMA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

2Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for PSMA4 Gene

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🧬 Gene Info

Gene Symbol	PSMA4
Full Name	Proteasome Subunit Alpha 4
Chromosome	15q21.3
Function	This ring serves as the gatekeeper for the proteolytic chamber, controlling access of substrates to the catalytic beta subunits.
Primary Expression	all tissues, with high expression in metabolically active cells:
Molecular Weight	26 kDa
UniProt ID	P25789
NCBI Gene ID	5685
Ensembl ID	ENSG00000123131
OMIM	176844
GeneCards	PSMA4
Human Protein Atlas	PSMA4
Brain	Highest expression in cortex, hippocampus, and cerebellum
Neuronal subtypes	Expressed in both excitatory glutamatergic neurons and inhibitory GABAergic neurons
Glial cells	Present in astrocytes and microglia, where it supports protein homeostasis during neuroinflammation
Associated Diseases	neurodegeneration
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSMA4 — AlphaFold P25789 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMA4 Gene

gene · 956 words

→

PSMA4 Protein

protein · 793 words

→

Pathway Diagram

flowchart TD
    N0["PSMA4"]
    N1["PSMB1"]
    N1 -->|"associated with"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (2)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PSMA4	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PSMA4	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PSMB1	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMA4 in their description or question text

No additional research found