concept

PI3K/AKT SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

17Outgoing

9Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K/AKT SIGNALING PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_SIGNALING_PATHWAY["PI3K/AKT SIGNALING PATHWAY"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| Apoptosis["Apoptosis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| amyloid_beta_neurotoxicity["amyloid-beta neurotoxicity"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"involved_in"| NAFLD["NAFLD"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"upstream_of"| BCL2["BCL2"]
    PI3K_AKT_SIGNALING_PATHWAY -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| BAX["BAX"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| oxidative_stress["oxidative stress"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| endoplasmic_reticulum_stress["endoplasmic reticulum stress"]
    FDX1_Downregulation["FDX1 Downregulation"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    NUP85["NUP85"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY
    LY290004["LY290004"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    Osteoking["Osteoking"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    SQDS["SQDS"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    GHYSJ["GHYSJ"] -->|"regulates"| PI3K_AKT_SIGNALING_PATHWAY

Outgoing (17)

Target	Relation	Type	Str
Apoptosis	regulates	process	0.90
apoptosis	regulates	process	0.90
Cell Survival	activates	process	0.90
Cell Proliferation	activates	process	0.90
amyloid-beta neurotoxicity	inhibits	process	0.80
NAFLD	involved_in	disease	0.80
BCL2	upstream_of	protein	0.80
Alzheimer's disease	protects_against	disease	0.78
BAX	regulates	protein	0.75
Alzheimer's disease	associated_with	disease	0.70
cerebral ischemia-reperfusion injury	associated_with	disease	0.70
blood-brain barrier damage	protects_against	process	0.70
neurological function recovery	activates	process	0.70
endoplasmic reticulum stress	inhibits	process	0.70
oxidative stress	inhibits	process	0.70
neuronal apoptosis	inhibits	process	0.70
inflammatory responses	inhibits	process	0.70

Incoming (9)

Source	Relation	Type	Str
FDX1 Downregulation	activates	mechanism	0.95
LY290004	inhibits	drug	0.90
PI3K	part_of	gene	0.90
NUP85	modulates	protein	0.90
Osteoking	activates	drug	0.85
LY294002	inhibits	compound	0.85
natural products	targets	compound	0.85
SQDS	inhibits	drug	0.82
GHYSJ	regulates	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT SIGNALING PATHWAY in their description or question text

No additional research found