gene

PDE10A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE10A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

1Hypotheses

0Analyses

5Outgoing

7Incoming

0Experiments

0Debates

Summary

PDE10A — Phosphodiesterase 10A

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🧬 Gene Info

Gene Symbol	PDE10A
Full Name	Phosphodiesterase 10A
Function	PDE10A has unique substrate specificity
Primary Expression	striatum, affected in HD
Pathways	Apoptosis
UniProt ID	O76074
Ensembl ID	ENSG00000112541
GeneCards	PDE10A
Human Protein Atlas	PDE10A
Morphology	pyramidal neuron (source: Cell Ontology)
Associated Diseases	neurodegeneration
Known Drugs/Compounds	TP-10
Interactions	AND, APOPTOSIS, CANCER, DNA, MITOCHONDRIAL DYSFUNCTION
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PDE10A — AlphaFold O76074 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDE10A["PDE10A"]
    Tumor{"Tumor"}
    PDE10A -->|"inhibits"| Tumor
    Cancer{"Cancer"}
    PDE10A -->|"inhibits"| Cancer
    Cardiovascular{"Cardiovascular"}
    PDE10A -->|"inhibits"| Cardiovascular
    Apoptosis(["Apoptosis"])
    PDE10A -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    PDE10A -->|"implicated in"| neurodegeneration
    FOXO3["FOXO3"]
    FOXO3 -->|"contributes to"| PDE10A
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"activates"| PDE10A
    CANCER["CANCER"]
    CANCER -->|"inhibits"| PDE10A
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| PDE10A
    style PDE10A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
cAMP	downstream_of	molecule	0.85
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Apoptosis	activates	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
TP-10	inhibits	drug	0.95
AND	inhibits	gene	0.60
DNA	activates	gene	0.60
FOXO3	contributes_to	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDE10A Inhibition to Bypass RGS6 Deficiency via cAMP Pathway	0.224	neurodegeneration	Does RGS6 upregulation or D2 autorecepto

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDE10A in their description or question text

No additional research found