| Gene Symbol | PDE10A |
| Full Name | Phosphodiesterase 10A |
| Function | PDE10A has unique substrate specificity |
| Primary Expression | striatum, affected in HD |
| Pathways | Apoptosis |
| UniProt ID | O76074 |
| Ensembl ID | ENSG00000112541 |
| GeneCards | PDE10A |
| Human Protein Atlas | PDE10A |
| cAMP hydrolysis | Primary substrate |
| cGMP hydrolysis | Secondary substrate |
| Dual-specificity | Rare among PDE family members |
| Basal activity | High constitutive activity |
| Phosphorylation | Can be regulated by PKA |
| Cellular localization | Primarily cytosolic |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | TP-10 |
| Interactions | AND, APOPTOSIS, CANCER, DNA, MITOCHONDRIAL DYSFUNCTION |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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