gene

PARP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

19Outgoing

3Incoming

0Experiments

0Debates

Summary

PARP2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, interacts with. Associated with Aging, Als, Atherosclerosis. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARP2
Chromosome	14q13.2
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most tissues, with high expression in brain regions including the hippocampus, cortex, and cerebellum, where it supports neur
Molecular Weight	62 kDa
Amino Acids	583 aa
GeneCards	PARP2
Human Protein Atlas	PARP2
Exon 1	5' UTR and start codon
Exons 2-10	Coding sequence
Exon 11	3' UTR with polyadenylation signal
Associated Diseases	ALS
Interactions	AGING, ALOX12, DNA, PARP1, TNKS
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PARP2 Gene

gene · 866 words

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PARP2 Protein

protein · 746 words

→

Pathway Diagram

graph TD
    PARP2["PARP2"]
    SOX2["SOX2"]
    SOX2 -->|"interacts_with"| PARP2
    Cardiovascular{"Cardiovascular"}
    PARP2 -->|"inhibits"| Cardiovascular
    Diabetes{"Diabetes"}
    PARP2 -->|"inhibits"| Diabetes
    Aging{"Aging"}
    PARP2 -->|"inhibits"| Aging
    Als{"Als"}
    PARP2 -->|"inhibits"| Als
    Atherosclerosis{"Atherosclerosis"}
    PARP2 -->|"inhibits"| Atherosclerosis
    Fatty_Liver{"Fatty Liver"}
    PARP2 -->|"inhibits"| Fatty_Liver
    Obesity{"Obesity"}
    PARP2 -->|"inhibits"| Obesity
    PARP1["PARP1"]
    PARP2 -->|"associated_with"| PARP1
    PARP3["PARP3"]
    PARP2 -->|"associated_with"| PARP3
    TNKS["TNKS"]
    PARP2 -->|"inhibits"| TNKS
    AGING["AGING"]
    PARP2 -->|"inhibits"| AGING
    DNA["DNA"]
    PARP2 -->|"inhibits"| DNA
    Cholesterol(["Cholesterol"])
    PARP2 -->|"inhibits"| Cholesterol
    Dna_Repair(["Dna Repair"])
    PARP2 -->|"inhibits"| Dna_Repair

Outgoing (19)

Target	Relation	Type	Str
Fatty Liver	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Lipid Metabolism	associated_with	pathway	0.60
DNA	inhibits	gene	0.60
Cholesterol	inhibits	pathway	0.60
Dna Repair	inhibits	pathway	0.60
AGING	inhibits	gene	0.60
PARP1	associated_with	gene	0.60
ALS	associated_with	disease	0.60
necroptosis	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
PARP3	associated_with	gene	0.60
TNKS	inhibits	gene	0.60
TGF	co_expressed_with	protein	0.50

Incoming (3)

Source	Relation	Type	Str
PARP1	activates	gene	0.60
ALOX12	activates	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARP2 in their description or question text

No additional research found