Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MUTANT P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MUTANT P53 |
| Key Genes/Proteins | AND, APOPTOSIS, BCL-2, CANCER, DR5, P53 |
| Related Diseases | ALS, Cancer, Lymphoma |
| Related Pathways | Apoptosis |
graph TD
MUTANT_P53["MUTANT P53"]
MUTANT_P53 -->|"causes"| malignant_transformation["malignant transformation"]
MUTANT_P53 -->|"causes"| metastatic_phenotype["metastatic phenotype"]
MUTANT_P53 -->|"inhibits"| wild_type_p53["wild-type p53"]
MUTANT_P53 -->|"risk_factor_for"| cancer["cancer"]
MUTANT_P53 -->|"causes"| genetic_instability["genetic instability"]
MUTANT_P53 -->|"regulates"| ferroptosis["ferroptosis"]
MUTANT_P53 -->|"inhibits"| Cancer["Cancer"]
MUTANT_P53 -->|"inhibits"| Lymphoma["Lymphoma"]
TRAIL["TRAIL"] -->|"inhibits"| MUTANT_P53
APOPTOSIS["APOPTOSIS"] -->|"activates"| MUTANT_P53
BCL_2["BCL-2"] -->|"inhibits"| MUTANT_P53| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MUTANT P53 | data_in | dataset_row | 0.00 |
| malignant transformation | causes | phenotype | 0.90 |
| metastatic phenotype | causes | phenotype | 0.90 |
| wild-type p53 | inhibits | protein | 0.90 |
| cancer | risk_factor_for | disease | 0.90 |
| genetic instability | causes | phenotype | 0.80 |
| stemness | associated_with | phenotype | 0.80 |
| ferroptosis | regulates | phenotype | 0.70 |
| Cancer | inhibits | disease | 0.65 |
| Lymphoma | inhibits | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| APOPTOSIS | activates | gene | 0.60 |
| P53 | inhibits | gene | 0.60 |
| DR5 | inhibits | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| B Cell | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MUTANT P53 | data_in | dataset_row | 0.00 |
| TRAIL | inhibits | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MUTANT P53 in their description or question text
No additional research found