gene

MECOM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MECOM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for MECOM Gene

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🧬 Gene Info

Gene Symbol	MECOM
Chromosome	3q26
Protein Type	Transcription Factor
Function	The MECOM gene encodes a protein involved in various neurological processes.
Primary Expression	various brain regions including cortex, hippocampus, and cerebellum
Amino Acids	725 aa
Exons	16
Pathways	TGF-β signaling
UniProt ID	Q03112
NCBI Gene ID	2122
Ensembl ID	ENSG00000085276
GeneCards	MECOM
Human Protein Atlas	MECOM
Associated Diseases	neurodegeneration
Interactions	AND, CANCER, EGFR, HDSP, HOXA10-HOXA9, SPINK1
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MECOM — AlphaFold Q03112 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MECOM Gene

gene · 669 words

→

MECOM Gene — MDS1 and EVI1 Complex

protein · 1204 words

→

Pathway Diagram

graph TD
    MECOM["MECOM"]
    SPINK1["SPINK1"]
    MECOM -->|"activates"| SPINK1
    HOXA10_HOXA9["HOXA10-HOXA9"]
    MECOM -->|"activates"| HOXA10_HOXA9
    Cancer{"Cancer"}
    MECOM -->|"activates"| Cancer
    Tumor{"Tumor"}
    MECOM -->|"activates"| Tumor
    TRIM25["TRIM25"]
    MECOM -->|"activates"| TRIM25
    EGFR["EGFR"]
    MECOM -->|"activates"| EGFR
    CANCER["CANCER"]
    MECOM -->|"activates"| CANCER
    neurodegeneration["neurodegeneration"]
    MECOM -->|"implicated in"| neurodegeneration
    HDSP["HDSP"]
    HDSP -->|"interacts with"| MECOM
    style MECOM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
SPINK1	activates	gene	0.90
HOXA10-HOXA9	activates	gene	0.80
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
CANCER	activates	gene	0.60
TRIM25	activates	gene	0.60
EGFR	activates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
HDSP	interacts_with	protein	0.90
AND	activates	gene	0.60
SPINK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MECOM in their description or question text

No additional research found