gene

KAT7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

15Outgoing

4Incoming

0Experiments

0Debates

Summary

KAT7 (HBO1/MYST2) is a histone acetyltransferase of the MYST family that catalyzes histone H4 acetylation, playing essential roles in DNA replication, transcription regulation, chromatin dynamics, and cellular homeostasis.

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🧬 Gene Info

Gene Symbol	KAT7
Full Name	Lysine Acetyltransferase 7 (HBO1/MYST2)
Aliases	HBO1/MYST2
Chromosome	17q21.33.
Protein Type	Transferase
Function	is a member of the MYST family of histone acetyltransferases (HATs).
Amino Acids	611 aa
Pathways	NF-κB
UniProt ID	O95251
NCBI Gene ID	11143
Ensembl ID	ENSG00000136541
OMIM	609593
GeneCards	KAT7
Human Protein Atlas	KAT7
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, LAMP2, NLRP3, STING
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KAT7 — AlphaFold O95251 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KAT7 — Lysine Acetyltransferase 7 (HBO1/MYST2)

gene · 994 words

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Pathway Diagram

graph TD
    KAT7["KAT7"]
    Ms{"Ms"}
    KAT7 -->|"activates"| Ms
    Mtor(["Mtor"])
    KAT7 -->|"regulates"| Mtor
    neurodegeneration["neurodegeneration"]
    KAT7 -->|"implicated in"| neurodegeneration
    MTOR["MTOR"]
    MTOR -->|"regulates"| KAT7
    MTORC1["MTORC1"]
    MTORC1 -->|"regulates"| KAT7
    LAMP2["LAMP2"]
    LAMP2 -->|"activates"| KAT7
    CANX["CANX"]
    CANX -->|"regulates"| KAT7
    style KAT7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.90
Mitochondrial DNA-driven innate immune signaling	regulates	pathway	0.90
Ms	activates	disease	0.65
CANX	regulates	gene	0.60
LAMP2	activates	gene	0.60
MTOR	regulates	gene	0.60
NLRP3	inhibits	gene	0.60
STING	inhibits	gene	0.60
neuroinflammation	activates	disease	0.60
MTORC1	regulates	gene	0.60
Mtor	regulates	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
synaptic plasticity	participates_in	pathway	0.60
AND	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
MTOR	regulates	gene	0.60
LAMP2	activates	gene	0.60
CANX	regulates	gene	0.60
MTORC1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KAT7 in their description or question text

No additional research found