RPL23A

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This page aggregates everything SciDEX knows about RPL23A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Ribosomal Protein L23a (RPL23A)

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graph TD
    RPL23A["RPL23A ribosomal protein"]
    HERC3["HERC3 E3 ubiquitin ligase"]
    ribosome["60S ribosomal subunit"]
    protein_synthesis["Protein synthesis"]
    ER_stress["ER stress response"]
    UPR["Unfolded protein response"]
    proteostasis["Cellular proteostasis"]
    mitochondria["Mitochondrial dysfunction"]
    oxidative_stress["Oxidative stress"]
    autophagy["Autophagy pathway"]
    neuronal_death["Neuronal cell death"]
    neurodegeneration["Neurodegeneration"]
    tau_protein["Tau protein aggregation"]
    amyloid["Amyloid beta accumulation"]
    synaptic_loss["Synaptic dysfunction"]
    
    RPL23A -->|"assembles into"| ribosome
    ribosome -->|"enables"| protein_synthesis
    protein_synthesis -->|"maintains"| proteostasis
    HERC3 -->|"ubiquitinates"| RPL23A
    HERC3 -->|"regulates degradation"| RPL23A
    
    proteostasis -->|"dysfunction leads to"| ER_stress
    ER_stress -->|"activates"| UPR
    UPR -->|"chronic activation"| mitochondria
    mitochondria -->|"generates"| oxidative_stress
    
    proteostasis -->|"impairment triggers"| autophagy
    autophagy -->|"failure promotes"| tau_protein
    autophagy -->|"failure promotes"| amyloid
    
    oxidative_stress -->|"induces"| neuronal_death
    tau_protein -->|"causes"| synaptic_loss
    amyloid -->|"causes"| synaptic_loss
    synaptic_loss -->|"leads to"| neurodegeneration
    neuronal_death -->|"results in"| neurodegeneration
    
    style RPL23A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style ribosome fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style protein_synthesis fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style proteostasis fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style HERC3 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style ER_stress fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style UPR fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style mitochondria fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style oxidative_stress fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style autophagy fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style neuronal_death fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style neurodegeneration fill:#3a2a1a,stroke:#ffa726,stroke-width:3px
    style tau_protein fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style amyloid fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style synaptic_loss fill:#3a1a1a,stroke:#ef5350,stroke-width:2px

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