| Gene Symbol | HERC3 |
| Full Name | HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3 |
| Chromosome | 4q22.1 |
| Protein Type | Ligase |
| Function | encodes a HECT domain E3 ubiquitin ligase that plays critical roles in protein quality control, autophagy, and NF-κB signaling. |
| Primary Expression | Brain (substantia nigra, cortex), Liver, Lung |
| Molecular Weight | 280 kDa |
| Amino Acids | 528 aa |
| Pathways | NF-κB signaling |
| UniProt ID | Q9NPA8 |
| NCBI Gene ID | 57524 |
| Ensembl ID | ENSG00000163795 |
| OMIM | 609419 |
| GeneCards | HERC3 |
| Human Protein Atlas | HERC3 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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