| Gene Symbol | ent-gene-ce4049d6 |
| Subcellular Localization | **: In cortical and hippocampal pyramidal neurons, HCN1 is enriched in dendritic compartments where it modulates synapti |
| Voltage dependence | Activation occurs at potentials more negative than -50 mV, with half-activation (V½) around -70 to -90 mV depending on cell type |
| cAMP modulation | Direct binding of cyclic adenosine monophosphate (cAMP) shifts the voltage activation curve depolarized by ~10-15 mV, providing neuromodulatory control |
| Kinetic properties | HCN1 exhibits fast activation and slow deactivation kinetics compared to other HCN isoforms, making it particularly effective for temporal integration |
| Subcellular localization | In cortical and hippocampal pyramidal neurons, HCN1 is enriched in dendritic compartments where it modulates synaptic integration and back-propagating action potentials[3] |
| TRIP8b | Tetratricopeptide repeat-containing Rab8b-interacting protein that controls HCN1 surface expression and trafficking[4] |
| Filamin A | Scaffold protein linking HCN1 to the actin cytoskeleton |
| Mint1/X11 | Adapter protein that modulates HCN1 channel density at synapses |
| Depolarized resting potential | HCN1 channels conduct inward current at rest, depolarizing the membrane potential toward -70 mV |
| Reduced input resistance | HCN1 conductance decreases membrane input resistance, affecting synaptic integration |
| Fast temporal integration | Rapid activation/deactivation kinetics allow HCN1 neurons to follow high-frequency synaptic inputs |
| Theta rhythm generation | HCN1 in hippocampal CA1 pyramidal neurons contributes to theta oscillation (4-8 Hz) pacemaking[5] |
| Rebound burst firing | Post-inhibitory rebound mediated by Ih contributes to thalamic burst mode |
| Sleep spindles | HCN1 activity modulates thalamocortical oscillations during non-REM sleep |
| Sensory transmission | Dendritic Ih regulates sensory signal integration in thalamic circuits |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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