protein

GRNPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The crystal structure reveals that granulin domains fold into compact, cysteine-knot motifs that are highly resistant to proteolysis[^crystal2022]. Multiple granulin domains can stack together, creating a "beads-on-a-string" architecture.

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🔬 Protein Info

Gene Symbol	GRNPROTEIN
Protein Family	Granulin family, Progranulin
Function	is a secreted glycoprotein encoded by the GRN gene that functions as a multifunctional growth factor and lysosomal regulator.
Subcellular Localization	**: Secreted, lysosomal lumen
Molecular Weight	~63 kDa (full-length)
Amino Acids	593 amino acids
UniProt ID	P28799
GeneCards	GRNPROTEIN
Human Protein Atlas	GRNPROTEIN
Each granulin domain	~90 amino acids with 12 conserved cysteines forming 6 disulfide bonds
N-glycosylation	Multiple N-linked glycosylation sites in the granulin domains
Secretion	Processed through the secretory pathway and released as a full-length protein
Proteolytic processing	Cleaved by extracellular proteases (neutrophil elastase, proteinase 3, MMP-9) into functional granulin peptides (GRN A-G)[^proteolytic2021]
Molecular weight	~63 kDa (full-length, unglycosylated)
Subcellular localization	Secreted, lysosomal lumen
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	Actin, AD, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	926 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRNPROTEIN — AlphaFold P28799 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Progranulin Protein

protein · 2203 words

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Pathway Diagram

graph TD
    GRNPROTEIN["GRNPROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRNPROTEIN -->|"implicated_in"| neurodegeneration
    style GRNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GRNPROTEIN in their description or question text

No additional research found