| Gene Symbol | GRNPROTEIN |
| Protein Family | Granulin family, Progranulin |
| Function | is a secreted glycoprotein encoded by the GRN gene that functions as a multifunctional growth factor and lysosomal regulator. |
| Subcellular Localization | **: Secreted, lysosomal lumen |
| Molecular Weight | ~63 kDa (full-length) |
| Amino Acids | 593 amino acids |
| UniProt ID | P28799 |
| GeneCards | GRNPROTEIN |
| Human Protein Atlas | GRNPROTEIN |
| Each granulin domain | ~90 amino acids with 12 conserved cysteines forming 6 disulfide bonds |
| N-glycosylation | Multiple N-linked glycosylation sites in the granulin domains |
| Secretion | Processed through the secretory pathway and released as a full-length protein |
| Proteolytic processing | Cleaved by extracellular proteases (neutrophil elastase, proteinase 3, MMP-9) into functional granulin peptides (GRN A-G)[^proteolytic2021] |
| Molecular weight | ~63 kDa (full-length, unglycosylated) |
| Subcellular localization | Secreted, lysosomal lumen |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Interactions | Actin, AD, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | GRN/progranulin lysosomal insufficiency across FTD |
| KG Connections | 930 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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