concept

FUMARATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUMARATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

11Outgoing

3Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FUMARATE

Pathway Diagram

graph TD
    FUMARATE[FUMARATE]
    FUMARATE -->|inhibits| PRKN[PRKN]
    FUMARATE -->|mediates| Succination[Succination]
    FUMARATE -->|inhibits| PINK1_Parkin_Mediated_Mitophag[PINK1-Parkin-Mediated Mitophagy]
    FUMARATE -->|inhibits| Mitophagy[Mitophagy]
    FUMARATE -->|inhibits| PARKIN[PARKIN]
    FUMARATE -->|binds| PRKN_Cysteine_323[PRKN Cysteine 323]
    FUMARATE -->|binds| PRKN_Cysteine_451[PRKN Cysteine 451]
    FUMARATE -->|binds| KEAP1[KEAP1]
    FUMARATE -->|contributes to| Parkinson_s_Disease[Parkinson's Disease]
    TCA_Cycle[TCA Cycle] -->|product_of| FUMARATE
    de_novo_purine_synthesis[de novo purine synthesis] -->|regulates| FUMARATE
    ADSL[ADSL] -->|regulates| FUMARATE

Outgoing (11)

Target	Relation	Type	Str
PRKN	inhibits	protein	0.95
PRKN	modulates	protein	0.95
Succination	mediates	process	0.95
PINK1-Parkin-Mediated Mitophagy	inhibits	pathway	0.95
Mitophagy	inhibits	process	0.95
PARKIN	inhibits	entity	0.92
PRKN Cysteine 323	binds	biomarker	0.90
PRKN Cysteine 451	binds	biomarker	0.90
KEAP1	binds	protein	0.85
Parkinson's Disease	contributes_to	disease	0.85
PTEN	regulates	protein	0.70

Incoming (3)

Source	Relation	Type	Str
TCA Cycle	product_of	pathway	0.95
ADSL	regulates	gene	0.70
de novo purine synthesis	regulates	pathway	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FUMARATE in their description or question text

No additional research found