protein

EPAS1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPAS1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The basic helix-loop-helix (bHLH) domain serves as the primary DNA-binding module. This domain recognizes and binds to the hypoxia response element (HRE) with the consensus sequence 5'-RCGTG-3' found in the promoters of target genes.

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🔬 Protein Info

Gene Symbol	EPAS1PROTEIN
Full Name	EPAS1 / HIF-2α
Protein Family	bHLH-PAS transcription factor family
Protein Type	Transcription Factor
Function	is a member of the HIF family of transcription factors that serve as the master regulators of cellular oxygen homeostasis.
Primary Expression	Highest in endothelial cells, neurons, cardiomyocytes, type II pneumocytes
Subcellular Localization	promoters of target genes
Molecular Weight	~96-118 kDa (depending on post-translational modifications)
UniProt ID	Q9Y5Q3
GeneCards	EPAS1PROTEIN
Human Protein Atlas	EPAS1PROTEIN
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections	488 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: EPAS1PROTEIN — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

epas1-protein

protein · 2900 words

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Pathway Diagram

graph TD
    EPAS1PROTEIN["EPAS1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    EPAS1PROTEIN -->|"implicated_in"| neurodegeneration
    style EPAS1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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Related Research

Hypotheses and analyses mentioning EPAS1PROTEIN in their description or question text

No additional research found