Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Astrocyte reactivity signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Adenosine-Astrocyte Metabolic Reset | 0.730 | neurodegeneration | Sleep disruption as cause and consequenc |
| Astrocyte-Mediated Neuronal Epigenetic Rescue | 0.725 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Astroglial Gap Junction Coordination via Connexin-43 Phospho | 0.720 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Mechanosensitive Ion Channel Reprogramming | 0.700 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th | 0.695 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Lipid Droplet Dynamics as Phenotype Switches | 0.666 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.860
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.791
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| TREK-1 regulation of conventional outflow facility in mouse eyes | validation | ocular hypertension | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on TREK-1 currents in human primary TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | primary human trabecular meshw | proposed | N/A |
| TREK-1 effects on IOP in DEX-induced mouse OHT model | validation | dexamethasone-induced ocular h | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on K2P channel transcriptome in mouse TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | mouse trabecular meshwork cell | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| TREK-1 effects on spontaneous OHT in rats using telemetry | validation | spontaneous ocular hypertensio | 0.800 | 0.00 | rat eyes | proposed | N/A |
| TREK-1 localization in trabecular meshwork by immunohistochemistry | exploratory | ocular hypertension | 0.800 | 0.00 | trabecular meshwork tissue | proposed | N/A |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Levodopa-Induced Dyskinesias Mechanism — Experiment Design | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti | validation | Neurodegeneration | 0.400 | 0.50 | human | completed | $3,000,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | completed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991] | Zhang Y, Kini SA, Mishkanian SA, Yarishk | Science | 2025 | 1 |
| Identification of mechanosensitive ion channel-related molecular subtypes and ke [PMID:40950697] | Zhang L, Wang L, Wang M, Peng K, Chen H, | Transl Cancer Res | 2025 | 1 |
| Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | Invest Ophthalmol Vis Sci | 2025 | 1 |
| Inflammation alters the expression and activity of the mechanosensitive ion chan [PMID:39789885] | Ren J, Zhan C, Lin Y | Eur J Orthod | 2024 | 1 |
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| GJA1-20k and Mitochondrial Dynamics. [PMID:35399255] | Shimura D, Shaw RM | Front Physiol | 2022 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706] | Packer JS, Zhu Q, Huynh C, Sivaramakrish | Science | 2019 | 1 |
| Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341] | Grady JM, Maitner BS, Winter AS, Kaschne | Science | 2019 | 1 |
| A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793] | Wang Z, DeWitt JC, Higgins CP, Cousins I | Environ Sci Technol | 2017 | 1 |
| Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789] | Scheffer DI, Shen J, Corey DP, Chen ZY | J Neurosci | 2015 | 1 |
| Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944] | Li X, Zhao H, Tan X, Kostrzewa RM, Du G, | Glia | 2015 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| Chapter 6: Structural variation and medical genomics. [PMID:23300412] | Raphael BJ | PLoS Comput Biol | 2012 | 1 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Astrocyte reactivity signaling in their description or question text