Aggregation

Can computational de novo protein binder design produce stable binders that bloc

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Can computationally designed binders against alpha-synuclein realistically trans

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

HSP90-Tau Disaggregation Complex Enhancement

Score: 0.551 · Alzheimer's Disease · 2026-04-02

## **Molecular Mechanism and Rationale** The heat shock protein 90 (HSP90) chaperone system represents a critical cellu

Microbial Metabolite-Mediated α-Synuclein Disaggregation

Score: 0.511 · neurodegeneration · 2026-04-02

Specific gut bacterial strains produce short-chain fatty acids (SCFAs) that cross the blood-brain barrier and directly m

Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate

Score: 0.500 · molecular biology · 2026-04-21

## Mechanistic Overview Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate starts from the claim that mod

G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neura

Score: 0.490 · neurodegeneration · 2026-04-22

## Mechanistic Overview G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neural Circuits start

GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and Aggregation

Score: 0.429 · neurodegeneration · 2026-04-18

## Mechanistic Overview GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and Aggregation starts from the claim th

P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription vi

Score: 0.423 · neurodegeneration · 2026-04-22

## Mechanistic Overview P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription via Calcineurin/NF

Direct cystatin C inhibition of tau aggregation

Score: 0.390 · neurodegeneration · 2026-04-25

Cystatin C binds tau through its cystatin-like domain, sequestering monomeric tau and preventing β-sheet aggregation. Th

Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Aggregation Seeding

Score: 0.360 · neurodegeneration · 2026-04-21

## Mechanistic Overview Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Aggregation Seeding starts from the cl

Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Tha

Score: 0.105 · molecular biology · 2026-04-18

## Mechanistic Overview Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct Protein