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mechanism 3,015 words KG: ent-gene-acc6d764
Contents

MAPT→Tau→Aggregation→PSP Causal Chain

🔬 Protein Info
Gene Symbolent-gene-acc6d764
PhosphorylationRegulates tau-microtubule interaction
Isoforms3R (3 repeats) vs 4R (4 repeats) from alternative splicing
Post-translational modificationsPhosphorylation, acetylation, ubiquitination, methylation
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (5)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Vagal Afferent Microbial Signal Modulation
Score: 0.66Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.63Vocal Cord Neuroplasticity Stimulation
Score: 0.52

Related Analyses (28)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (25)

Double depletion rescue experiment: tau and MAP6 co-depletio
exploratory · proposed · Score: 0.95Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90

Knowledge Graph (4 edges)

h-ea85fbfb90 targets ent-gene-acc6d764
ent-gene-acc6d764 targeted_by h-ea85fbfb90
ent-gene-acc6d764 data_in benchmark_ot_ad_answer_key:MAPT
benchmark_ot_ad_answer_key:MAPT data_in ent-gene-acc6d764

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