| Gene Symbol | ent-gene-a6935314 |
| Chromosome | 4q22.1 |
| Function | Alpha-Synuclein Aggregation |
| Synaptic vesicle trafficking | Regulates synaptic vesicle pool size and neurotransmitter release |
| Dopamine synthesis | Modulates tyrosine hydroxylase activity in dopaminergic neurons |
| Chaperone activity | C-terminal region exhibits molecular chaperone function |
| Lipid binding | N-terminal domain binds synaptic vesicles, influencing membrane curvature |
| Antioxidant function | Acts as a molecular scavenger for reactive oxygen species |
| ER-Golgi trafficking | Participates in vesicular transport between cellular compartments |
| High dopamine levels | Dopamine can be oxidized to form toxic quinones that interact with alpha-synuclein |
| Iron accumulation | The substantia nigra has high iron content, promoting oxidative stress |
| High metabolic demand | Dopaminergic neurons have high energy requirements |
| Autonomic regulation | Less efficient protein quality control mechanisms |
| Rep1 | Microsatellite in promoter region affects expression levels |
| SNPs in linkage disequilibrium | Multiple risk haplotypes identified |
| SNCA triplication | Causes PARK4 with early-onset PD and dementia |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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