gene 1,361 words KG: ANKRD11
Contents

ANKRD11 — Ankyrin Repeat Domain 11

🧬 Gene Info
Gene SymbolANKRD11
Full NameAnkyrin Repeat Domain 11
Chromosome16q24.3
Protein TypeGene
Function### Transcriptional Regulation
Primary Expressionthe brain and has been implicated in neurodevelopment and neurodegeneration
Molecular Weight256 kDa
Amino Acids556 aa
Exons13
GeneCardsANKRD11
Human Protein AtlasANKRD11
Ankyrin repeats (N-terminal)8 ankyrin repeat motifs that mediate protein-protein interactions
Nuclear localization signalsPromote nuclear import
PEST sequencesRegulatory sequences affecting protein stability
Histone acetylationANKRD11 interacts with p300/CBP to enhance histone acetylation at target gene promoters
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
BRD4 (Bromodomain-Containing Protein 4)
gene · KG edge: contributes_to
HDAC8 Gene
gene · KG edge: associated_with
NIPBL - Nipped-B Like (Cohesin Loader)
gene · KG edge: associated_with
RAD21 — Cohesin Complex Component in Neurodegeneration
gene · KG edge: associated_with

Knowledge Graph (9 edges)

SMC1A associated_with ANKRD11
ANKRD11 associated_with NIPBL
ANKRD11 associated_with HDAC8
ANKRD11 associated_with SMC3
ANKRD11 contributes_to BRD4
ANKRD11 associated_with RAD21
ANKRD11 contributes_to Als
ANKRD11 data_in benchmark_ot_ad_answer_key:ANKRD11
benchmark_ot_ad_answer_key:ANKRD11 data_in ANKRD11

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)