Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Amyloid plaque: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | biomarker_for | disease | 0.95 |
| Alzheimer'S Disease | biomarker_for | disease | 0.95 |
| Neurodegeneration | causes | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Amyloid-Targeting Therapy | targets | mechanism | 0.95 |
| ST8SIA1 | inhibits | gene | 0.95 |
| Treat-To-Clearance Approach | regulates | mechanism | 0.92 |
| Aβ42 | promotes | protein | 0.90 |
| BRAIN-DERIVED TAU | correlates_with | protein | 0.88 |
| Cellular Senescence | promotes | process | 0.85 |
| BMAL1 | protects_against | gene | 0.70 |
| PSEN1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxic | 0.847 | neurodegeneration | Legacy Pre-Pipeline Hypothesis Import |
| Amyloid Plaque Clearance Triggers Downstream Reduction in Ta | 0.475 | - | Can CSF p-tau217 normalization serve as |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single nuclei transcriptomic and epigenomic profiling of 84 donors acr | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) integrates n | neuropathology | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| In late life, NfL demonstrated the strongest association with incident | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Complex gene expression differences were identified, ranging from glob | gene_expression | Alzheimer's disease | 0.500 | 0.00 | post_mortem_brain | extracted | N/A |
| A subset of donors with particularly severe cellular and molecular phe | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Midlife hypertension was associated with 0.15-SD faster NfL increase a | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| A subset of donors exhibited particularly severe cellular and molecula | computational | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Cell type-specific analysis identified early-phase loss of somatostati | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Single-cell/multiomics analysis of 84 human post-mortem brains reveale | computational | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Temporal analysis of gene expression differences across disease progre | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Amyloid plaque in their description or question text
No additional research found