concept

Aβ CLEARANCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Aβ CLEARANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

3Hypotheses

4Analyses

0Outgoing

22Incoming

0Experiments

4Debates

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💡 Concept Info

Name	Aβ CLEARANCE

Pathway Diagram

graph TD
    A__CLEARANCE[Aβ CLEARANCE]
    SQSTM1[SQSTM1] -->|involved_in| A__CLEARANCE
    MAP1LC3B[MAP1LC3B] -->|involved_in| A__CLEARANCE
    Astrocytic_Autophagy[Astrocytic Autophagy] -->|promotes| A__CLEARANCE
    ASTROCYTES[ASTROCYTES] -->|mediates| A__CLEARANCE
    astrocytic_autophagy[astrocytic autophagy] -->|modulates| A__CLEARANCE
    Autophagy[Autophagy] -->|mediates| A__CLEARANCE
    LPL[LPL] -->|modulates| A__CLEARANCE
    Autophagy_Induction[Autophagy Induction] -->|mediates| A__CLEARANCE
    ASTROCYTE[ASTROCYTE] -->|mediates| A__CLEARANCE

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (22)

Source	Relation	Type	Str
SQSTM1	involved_in	gene	0.95
MAP1LC3B	involved_in	gene	0.94
Astrocytic Autophagy	promotes	process	0.94
ASTROCYTES	mediates	cell_type	0.93
astrocytic autophagy	modulates	process	0.90
Autophagy	mediates	process	0.87
AUTOPHAGY	promotes	process	0.80
LPL	modulates	gene	0.80
TREM2	enhances	gene	0.80
Lyso-ChR2	associated_with	protein	0.80
Autophagy Induction	mediates	process	0.80
SYK	associated_with	gene	0.80
ASTROCYTE	mediates	cell_type	0.80
ASTROCYTES	mediates	cell_type	0.80
autophagy	activates	process	0.70
TFEB	enhances	gene	0.70
pericyte-specific PDGFRβ signaling	regulates	process	0.70
PDGFRβ signaling	regulates	pathway	0.70
LRP1	regulates	protein	0.70
APOE	regulates	gene	0.70
LRP1	enhances	gene	0.70
LRP1	modulates	protein	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Soluble LRP1 (sLRP1) Ectodomain Shedding as a Blood-Based In	0.680	-	What blood-brain barrier permeability ch
Reactive astrocyte glutamate-handling failure sustains dendr	0.490	neurodegeneration	Does tau dendritic missorting persist in
CYP2J2-Derived DHA Epoxides Modulate Microglial M2 Polarizat	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei