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PSEN1 Protein (Presenilin-1)

active
wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-proteins-psen1
Related Entities
PSEN1
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
42
Outgoing
99
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (141)
mentions🧫Adoptive transfer of TCRAβ-Tregs in AD mouse model80%
related🧫Adoptive transfer of TCRAβ-Tregs in AD mouse model72%
mentions🧫Neural Stem Cell Therapy for Alzheimer's Disease70%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%
mentions🧫Amyloid plaque load analysis in triple-mutant mouse brains70%
mentions📓SEA-AD Gene Expression Analysis: Microglia vs Neurons70%
see_also📓SEA-AD Gene Expression Analysis: Microglia vs Neurons70%
mentions🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%
mentions🧫Creation and validation of 3xAD-ChAT-Cre mouse model70%
mentions🧫Tet2 expression analysis in aged 2×Tg-AD mouse brains70%
related🔬Do β-amyloid plaques and neurofibrillary tangles cause or re70%
mentions🧫Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice70%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%
related🧫Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice63%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease63%
related🧫Tet2 expression analysis in aged 2×Tg-AD mouse brains63%
related🧫Creation and validation of 3xAD-ChAT-Cre mouse model63%
related🧫Amyloid plaque load analysis in triple-mutant mouse brains63%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise63%
see_also📖ABI3 Gene60%
see_also📖a2m60%
see_also📖ABCA2 Gene - ATP Binding Cassette Subfamily A Member 260%
see_also📖ABCA7 (Redirect)60%
see_also📖ACE Gene60%
see_also📖adam1060%
see_also📖adam1760%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬What are the mechanisms underlying selective vulnerability o50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
mentions🧪Transcriptional Autophagy-Lysosome Coupling50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%
mentions🧪Glial Glycocalyx Remodeling Therapy50%
mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying selective vulnerability o50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪GAP43-mediated tunneling nanotube stabilization enhances neu50%
mentions🧪Mitochondrial Calcium Buffering Enhancement via MCU Modulati50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
mentions🧪Epigenetic Memory Erasure via TET2 Activation50%
mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
mentions🧪TET2-Mediated Demethylation Rejuvenation Therapy50%
mentions🧪Biorhythmic Interference via Controlled Sleep Oscillations50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪Complement C1QA Spatial Gradient in Cortical Layers50%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying protein aggregation cross50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧪Autophagosome Maturation Checkpoint Control50%
mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%
mentions🧪Prefrontal sensory gating circuit restoration via PV interne50%
mentions🧪Multi-Modal CRISPR Platform for Simultaneous Editing and Mon50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%
related🔬RNA binding protein dysregulation across ALS FTD and AD50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
mentions🧪APOE Isoform Conversion Therapy50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🧪Chromatin Accessibility Restoration via BRD4 Modulation40%
mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%
mentions🔬What are the mechanisms underlying rna binding protein dysre40%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪SASP-Mediated Cholinergic Synapse Disruption40%
related🧪Glial Glycocalyx Remodeling Therapy40%
related🔬Epigenetic reprogramming in aging neurons40%
related🧪RAB27A-dependent extracellular vesicle engineering for mitoc40%
related🧪CX43 hemichannel engineering enables size-selective mitochon40%
related🧪Prefrontal sensory gating circuit restoration via PV interne40%
related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%
related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors40%
related🔬Epigenetic reprogramming in aging neurons40%
related🧪Heat Shock Protein 70 Disaggregase Amplification40%
related🔬Mitochondrial transfer between astrocytes and neurons40%
related🧪Prefrontal sensory gating circuit restoration via PV interne40%
related🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Astrocyte-Mediated Neuronal Epigenetic Rescue40%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr40%
related🧪Serine/Arginine-Rich Protein Kinase Modulation40%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer40%
related🧪Temporal TET2-Mediated Hydroxymethylation Cycling40%
related🔬Circuit-level neural dynamics in neurodegeneration — Analysi40%
related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna40%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu40%
related🧪Partial Neuronal Reprogramming via Modified Yamanaka Cocktai40%
related🧪Selective HDAC3 Inhibition with Cognitive Enhancement40%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy40%
related🧪Nutrient-Sensing Epigenetic Circuit Reactivation40%
related🧪Mitochondrial Calcium Buffering Enhancement via MCU Modulati40%
related🧪Biorhythmic Interference via Controlled Sleep Oscillations40%
related🧪Autophagosome Maturation Checkpoint Control40%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr40%
related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪Competitive APOE4 Domain Stabilization Peptides40%
related🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration40%
related🔬What are the mechanisms underlying mitochondrial transfer be40%
related🧪Astrocyte-Mediated Neuronal Epigenetic Rescue40%
related🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho40%
mentions🔬What are the mechanisms underlying protein aggregation cross40%
mentions🔬What are the mechanisms underlying microglia-astrocyte cross35%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 35%
mentions🔬What are the mechanisms underlying selective vulnerability o35%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬Epigenetic reprogramming in aging neurons35%
mentions🔬What are the mechanisms underlying apoe4 structural biology 35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp35%
mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
related🔬What are the mechanisms underlying tdp-43 phase separation t30%

💬 Discussion

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