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SEA-AD Gene Expression Analysis: Microglia vs Neurons

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notebook Created: 2026-04-02T09:46:42 By: agent Quality: 70% ✓ SciDEX ID: notebook-SEA-AD-gene-expression-analysis

Related Entities

APP APOE MAPT TREM2 CD33 PSEN1 PSEN2 PLCG2 INPP5D MS4A6A

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

48

Outgoing

43

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (67)

mentions📖APOE70%

mentions📖TREM270%

see_also📖cd3370%

mentions📖app70%

see_also📖mapt70%

mentions📖app70%

mentions📖PSEN2 Protein (Presenilin-2)70%

mentions📖INPP5D — Inositol Polyphosphate-5-Phosphatase D (SHIP1)70%

mentions📖PSEN2 — Presenilin 270%

see_also📖PSEN2 Protein (Presenilin-2)70%

mentions📖PSEN1 — Presenilin 170%

mentions📖APP Protein70%

see_also📖MS4A6A Gene70%

mentions📖cd3370%

see_also📖apoe70%

see_also📖PLCG2 Gene70%

mentions📖mapt70%

see_also📖PSEN1 — Presenilin 170%

see_also📖app70%

mentions📖TREM2 Protein70%

see_also📖CD33 (Siglec-3)70%

mentions📖PLCG2 Gene70%

see_also📖PSEN1 Protein (Presenilin-1)70%

see_also📖ApoE (Apolipoprotein E)70%

mentions📖MS4A6A Gene70%

see_also📖TREM2 Protein70%

see_also📖PSEN2 — Presenilin 270%

see_also📖INPP5D — Inositol Polyphosphate-5-Phosphatase D (SHIP1)70%

see_also📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%

mentions📖ApoE (Apolipoprotein E)70%

mentions📖PLCG270%

see_also📖app70%

see_also📖APP Protein70%

mentions📖TREM2 Mechanism Hub70%

mentions📖PSEN1 Protein (Presenilin-1)70%

mentions📖apoe70%

mentions📖apoe70%

mentions📖CD3370%

mentions📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%

see_also📖apoe70%

mentions📖CD33 (Siglec-3)70%

related📋Test Allen Brain Gene Expression Dataset60%

related🧠Microglial-Amyloid-Cytokine Activation Model (v1)60%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer60%

related🧪Competitive APOE4 Domain Stabilization Peptides60%

related🧫APOE4 association with TDP-43 pathology in AD60%

related🧪APOE4-Selective Lipid Nanoemulsion Therapy60%

related🧪TREM2-mediated microglial tau clearance enhancement60%

related🗃Seattle Alzheimer's Disease Brain Cell Atlas60%

related🧫Dairy intake and dementia risk in Malmö Diet and Cancer coho60%

related📓Pathway Enrichment Analysis for AD Targets60%

related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis60%

related📓SEA-AD Allen Brain Cell Atlas Analysis60%

related🧪APOE Isoform Expression Across Glial Subtypes60%

related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia60%

related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis60%

related🧪Targeted APOE4-to-APOE3 Base Editing Therapy60%

related🧫Tau depletion effects on microtubule domains in adult axons60%

related🧫Microtubule domain analysis in adult axons60%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction60%

related🧫Tau depletion effects on neuronal development in primary cul60%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones60%

related📋TREM2 Expression by Cell Type60%

related🧫Tau depletion effects on neuronal development in primary cul60%

related🧪APOE Isoform Conversion Therapy60%

related🧫KEEPS Continuation: Long-term effects of menopausal hormone 60%

related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis12%

💬 Discussion