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Amyloid plaque load analysis in triple-mutant mouse brains

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experiment Created: 2026-04-11T05:32:02 By: experiment_extractor Quality: 88% ✓ SciDEX ID: experiment-exp-4c97be59-973e-4997-bca9-8

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🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

42

Outgoing

39

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (79)

related🧫Abeta-induced cell death and aggregation in GD3S-deficient n100%

related🧫Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice100%

mentions📖app70%

mentions📖APP Amyloid Pathway in Alzheimer's Disease70%

mentions📖PSEN1 Presenilin 1 AD Causal Chain70%

mentions📖APP Gene Dosage Reduction Therapy for Down Syndrome70%

mentions📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai70%

mentions📖APP Processing and Amyloid-Beta Production70%

mentions📖APP-BACE1-Fe65 Complex70%

mentions📖APP-Overexpressing Neurons70%

mentions📖PSEN1 — Presenilin 170%

mentions📖APP Dutch Mutation (APP Dutch)70%

mentions📖PSEN1 Mutations in Alzheimer's Disease70%

mentions📖APP Swedish Mutation (APPswe)70%

mentions📖APP/PS1 Dual Transgenic Mouse Model70%

mentions📖APP/PS1 Double Transgenic Mouse Model70%

mentions📖APP Arctic Mutation (APP Arctic)70%

mentions📖APP Gene70%

mentions📖PSEN1-Mutant Neurons70%

mentions📖entities-psen170%

mentions📖APP Protein70%

mentions📖APP Flemish Mutation (APP Flemish)70%

mentions📖PSEN1 Protein (Presenilin-1)70%

related📖APP Gene Dosage Reduction Therapy for Down Syndrome63%

related📖APP Gene63%

related📖app63%

related📖PSEN1 Mutations in Alzheimer's Disease63%

related📖APP Protein63%

related📖PSEN1 Presenilin 1 AD Causal Chain63%

related📖APP Processing and Amyloid-Beta Production63%

related📖APP Dutch Mutation (APP Dutch)63%

related📖PSEN1 — Presenilin 163%

related📖APP Swedish Mutation (APPswe)63%

related📖entities-psen163%

related📖APP/PS1 Double Transgenic Mouse Model63%

related📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai63%

related📖APP Flemish Mutation (APP Flemish)63%

related📖APP Amyloid Pathway in Alzheimer's Disease63%

related📖PSEN1 Protein (Presenilin-1)63%

related📖APP-BACE1-Fe65 Complex63%

related📖APP-Overexpressing Neurons63%

related📖APP/PS1 Dual Transgenic Mouse Model63%

related📖APP Arctic Mutation (APP Arctic)63%

related📖PSEN1-Mutant Neurons63%

mentions📖Neurodegeneration60%

mentions📖PSEN2 Mutations in Alzheimer's Disease60%

mentions📖APP Mutations in Alzheimer's Disease60%

mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%

mentions📖Alzheimer's Disease60%

mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%

related📖Alzheimer's Disease60%

mentions📖Alzheimer's Disease Genetic Variants60%

mentions📖Prodromal Alzheimer's Disease60%

mentions📖Agitation in Alzheimer's Disease60%

mentions📖Preclinical Alzheimer's Disease60%

mentions📖Early-Onset Alzheimer's Disease (EOAD)60%

mentions📖TREM2 Variants in Alzheimer's Disease60%

mentions📖Investment Landscape: Alzheimer's Disease60%

mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%

related📖Alzheimer's Disease54%

related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%

related📖Prodromal Alzheimer's Disease54%

related📖Alzheimer's Disease vs Parkinson's Disease Compari54%

related📖Early-Onset Alzheimer's Disease (EOAD)54%

related📖APP Mutations in Alzheimer's Disease54%

related📖Investment Landscape: Alzheimer's Disease54%

related📖Neurodegeneration54%

related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%

related📖Preclinical Alzheimer's Disease54%

related📖Alzheimer's Disease Genetic Variants54%

related📖PSEN2 Mutations in Alzheimer's Disease54%

related📖Agitation in Alzheimer's Disease54%

related📖TREM2 Variants in Alzheimer's Disease54%

mentions📖app50%

mentions📖PSEN1 — Presenilin 150%

mentions📖gd3-synthase50%

mentions📖Ganglioside and Membrane Lipid Raft Dysfunction in 4R-Tauopa50%

mentions📖Memory Prosthetic BCI for Alzheimer's Disease44%

mentions📖Sphingolipid Metabolism Dysregulation in 4R-Tauopathies44%

💬 Discussion