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Epigenetic reprogramming in aging neurons

active
analysis Created: 2026-04-10T17:46:29 By: crosslink-v2 Quality: 50% ✓ SciDEX ID: analysis-SDA-2026-04-04-gap-epigenetic-r
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
133
Outgoing
49
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (182)
derives_from📓Epigenetic reprogramming in aging neurons — Notebook Stub100%
produces📓Epigenetic reprogramming in aging neurons — Notebook Stub100%
derives_from📓Epigenetic reprogramming in aging neurons — Analysis Noteboo100%
mentions📖DNA Damage Response and Repair in Neurodegeneration75%
mentions📖DNA Damage and Repair Dysfunction in PSP75%
mentions📖DNA Repair Therapy for Neurodegeneration75%
mentions📖DNA Damage Repair Therapy - Biomarker Guided75%
mentions📖DNA Sensing Pathways in Neurodegeneration75%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 75%
mentions📖DNA Damage Response in Corticobasal Syndrome75%
mentions📖DNA Damage Response in Neurons75%
mentions📖DNA Damage Repair Investment Landscape75%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#75%
mentions📖DNA Damage Repair Therapy for Neurodegeneration75%
mentions📖DNA Ligase IV Protein75%
mentions📖DNA-PKcs (PRKDC) Protein75%
mentions📖DNA Damage Response in Neurodegeneration75%
mentions📖DNA Damage Response in Corticobasal Syndrome75%
mentions📖DNA Methylation Biomarkers in Neurodegeneration75%
mentions📖DNA Methylation75%
mentions📖DNA Damage and Repair in Neurons75%
mentions📖DNA Repair Mechanisms in Neurodegeneration75%
mentions📖DNA Damage Response Impairment Pathway75%
mentions📖DNA Methylation in Neurodegeneration75%
mentions📖DNA Damage Response in Parkinson's Disease75%
mentions📖DNA Damage Response in Alzheimer's Disease75%
mentions📖DNA Ligase III Protein75%
mentions📖dna-damage-repair75%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration75%
mentions📖DNA Damage Response in 4R-Tauopathies75%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas75%
mentions📖DNA Damage Response in Alzheimer's Disease75%
related📖Mitochondria70%
related📖NAMPT Gene70%
related📖Mitochondria in Neurodegeneration70%
related📖Mitochondria-Lysosome Contact Site Dysfunction in Parkinson&70%
related📖Mitochondria-Lysosome Contact Site Dysfunction in Parkinson&70%
related📖Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypoth70%
related📖SMARCA470%
related📖Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegenerat70%
related📖Mitochondria-Lysosome Contact Sites in Parkinson's Dise70%
related📖Mitochondria-Lysosome Contact Sites Dysfunction in Parkinson70%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#67%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 67%
related📖DNA Damage Response in Alzheimer's Disease67%
related📖DNA Methylation in Neurodegeneration67%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration67%
related📖DNA Repair Therapy for Neurodegeneration67%
related📖DNA Damage Repair Therapy for Neurodegeneration67%
related📖DNA Damage Response in Corticobasal Syndrome67%
related📖DNA Damage Response in Parkinson's Disease67%
related📖DNA Damage Response in Neurons67%
related📖DNA Repair Mechanisms in Neurodegeneration67%
related📖DNA Sensing Pathways in Neurodegeneration67%
related📖dna-damage-repair67%
related📖DNA Damage Response in Neurodegeneration67%
related📖DNA Damage Repair Investment Landscape67%
related📖DNA Ligase IV Protein67%
related📖DNA Damage Response Impairment Pathway67%
related📖DNA Damage Response in Corticobasal Syndrome67%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas67%
related📖DNA Damage Response in Alzheimer's Disease67%
related📖DNA Damage Response and Repair in Neurodegeneration67%
related📖DNA Methylation67%
related📖DNA Damage Response in 4R-Tauopathies67%
related📖DNA-PKcs (PRKDC) Protein67%
related📖DNA Ligase III Protein67%
related📖DNA Methylation Biomarkers in Neurodegeneration67%
related📖DNA Damage Repair Therapy - Biomarker Guided67%
related📖DNA Damage and Repair Dysfunction in PSP67%
related📖DNA Damage and Repair in Neurons67%
related📖Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypoth63%
related📖Mitochondria-Lysosome Contact Site Dysfunction in Parkinson&63%
related📖Mitochondria-Lysosome Contact Sites Dysfunction in Parkinson63%
related📖Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegenerat63%
related📖Mitochondria63%
related📖Mitochondria in Neurodegeneration63%
related📖Mitochondria-Lysosome Contact Site Dysfunction in Parkinson&63%
related📖Mitochondria-Lysosome Contact Sites in Parkinson's Dise63%
related📖NAMPT Gene62%
mentions📖Huntington's Disease Somatic CAG Expansion and DNA Repa60%
mentions📖CBS DNA Damage Response Mechanisms60%
mentions📖mechanisms60%
mentions📖Alzheimer's Disease DNA Damage Repair and Chromatin Rem60%
mentions📖Mitochondrial DNA Replication60%
mentions📖TAR DNA-Binding Protein 43 (TDP-43)60%
mentions📖Parkinson's Disease DNA Damage Repair Therapeutic Compa60%
mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia60%
mentions📖Cell-Free DNA Biomarkers in Neurodegeneration60%
mentions📖cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneratio60%
related📖NAMPT Gene56%
related📖TAR DNA-Binding Protein 43 (TDP-43)54%
related📖Huntington's Disease Somatic CAG Expansion and DNA Repa54%
related📖Cell-Free DNA Biomarkers in Neurodegeneration54%
related📖Alzheimer's Disease DNA Damage Repair and Chromatin Rem54%
related📖mechanisms54%
related📖Parkinson's Disease DNA Damage Repair Therapeutic Compa54%
related📖CBS DNA Damage Response Mechanisms54%
related📖cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneratio54%
related📖Mitochondrial DNA Replication54%
related📖TDP-43 DNA Repair Mechanism in ALS and Dementia54%
related📖Neurodegeneration52%
related📖ai-tool-bioframe52%
related📖ai-tools-inference-bio52%
related📖ai-tool-alibaba-tongyi-qianwen-bio52%
related📖ai-tool-openai-codex-biology52%
related📖ai-tool-nucleus-dnastack52%
related📖ai-tool-biorxiv-literature-agent52%
mentions📖DALY Methodology — Neurodegeneration50%
mentions📖Mitochondrial Diseases and Neurodegeneration Comparison Matr50%
mentions📖Global Neurodegeneration Epidemiology50%
mentions📖China Neurodegeneration Epidemiology50%
mentions📖Potential Impact Measures — Neurodegeneration50%
mentions📖Neurodegeneration with Brain Iron Accumulation (NBIA)50%
mentions📖PLA2G6-Associated Neurodegeneration (PLAN)50%
mentions📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)50%
mentions📖India Neurodegeneration Epidemiology50%
mentions📖Disease Progression & Staging in Neurodegeneration50%
mentions📖Economic Burden — Neurodegeneration50%
mentions📖Manganese-Related Neurodegeneration (Manganism)50%
mentions📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)50%
mentions📖Sleep Disorders in Neurodegeneration50%
mentions📖European Neurodegeneration Epidemiology50%
mentions📖US Neurodegeneration Epidemiology50%
mentions📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)50%
mentions📖Familial vs Sporadic Neurodegeneration Comparison50%
mentions📖Neurodegeneration50%
mentions📖mitochondrial-dysfunction-neurodegeneration-comparison50%
mentions📖Japan Neurodegeneration Epidemiology50%
mentions📖Mitochondrial Membrane Protein-Associated Neurodegeneration 50%
related📖SIRT3 - Sirtuin 340%
related📖entities-psen140%
related📖atg740%
related📖entities-sirt140%
related📖LAMP1 Protein40%
related📖MDM2 Gene40%
related📖cd3340%
related📖GRIN2B — NMDA Receptor Subunit 2B40%
related📖AMPK Agonist Therapy for Neurodegeneration40%
related📖TREM2 Protein40%
related📖PGC1A Gene40%
related📖CD33 (Siglec-3)40%
related📖Tau Protein40%
related📖APP Gene Dosage Reduction Therapy for Down Syndrome40%
related📖AMPK (AMP-Activated Protein Kinase)40%
related📖Brain-Derived Neurotrophic Factor (BDNF)40%
related📖Glial Cell Derived Neurotrophic Factor (GDNF)40%
related📖PSEN1 Protein (Presenilin-1)40%
related📖PARP1 Gene40%
related📖cdk540%
related📖PSEN1 — Presenilin 140%
related📖BMAL1 (ARNTL) Gene40%
related📖DLG4 Gene - PSD-9540%
related📖ATG5 — Autophagy Related 540%
related📖NGF Gene40%
related📖BDNF Gene40%
related📖Lysosomal Associated Membrane Protein 1 (LAMP1)40%
related📖GDNF — Glial Cell Line-Derived Neurotrophic Factor40%
related📖BRD4 (Bromodomain-Containing Protein 4)40%
related📖sTREM2 (Soluble TREM2) - Biomarker40%
related📖trem2-alpha-synuclein-clearance-parkinsons40%
related📖SYN1 Gene40%
related📖ATG5 Protein40%
related📖CDK5 Gene40%
related📖CD33 Modulation Therapy for Neurodegeneration40%
related📖HDAC3 Gene40%
related📖ATG7 Gene40%
related📖TREM2 Mechanism Hub40%
related📖HDAC Inhibitors for Neurodegeneration — Investment Landscape40%
related📖app40%
related📖entities-gdnf40%
related📖CSF1R Protein (Colony Stimulating Factor 1 Receptor)40%
related📖APP Protein40%
related📖CSF1R — Colony Stimulating Factor 1 Receptor40%
related📖TREM2 Protein (Triggering Receptor Expressed on Myeloid Cell40%
related📖SIRT1 Gene40%
related📖First-in-Human 4R Tau Ligand Study in PSP (NCT07348276)40%
related📖PARP1 (Poly(ADP-Ribose) Polymerase 1)40%
related📖TET2 Gene40%
related📖entities-ngf40%
related📖SIRT6 Gene40%
related📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 240%

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