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Alzheimer's Disease Soluble Epoxide Hydrolase (sEH) Inhibitor Companies

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wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-companies-ad-seh-inhibitor-companie
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🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
205
Outgoing
215
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (302)
see_also📖Nabilone for Agitation in Alzheimer's Disease (NCT0451680%
see_also📖GSK4527226 (AL101) for Early Alzheimer's Disease (NCT0680%
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related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna80%
see_also📖The Alzheimer's Disease Tau Platform Clinical Trial (NC80%
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see_also📖Ozanimod for Alzheimer's Disease (NCT06862960)80%
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see_also📖MAR Polypill for Alzheimer's Disease (NCT06597058)80%
see_also📖Salivary Biomarkers for Alzheimer's Disease80%
see_also📖Gait Biomarkers for Alzheimer's Disease80%
see_also📖Cholinergic System Degeneration in Alzheimer's Disease80%
see_also📖ASN90 Phase 2 Trial - Early Alzheimer's Disease (NCT05680%
see_also📖Digital Biomarkers for Alzheimer's Disease80%
related🧪Prefrontal sensory gating circuit restoration via PV interne80%
related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation80%
see_also📖Latrepirdine (DMB-I) Phase 3 Trial for Alzheimer's Dise80%
see_also📖ASL Perfusion Biomarkers for Alzheimer's Disease80%
see_also📖Inflammatory Biomarkers in Alzheimer's Disease80%
see_also📖[F-18]Flornaptitril PET - Phase 3 for Alzheimer's Disea80%
see_also📖APOE4 and Alzheimer's Disease Risk80%
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see_also📖SHR-1707 for Alzheimer's Disease (NCT06199037)80%
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see_also📖Ubiquitin-Proteasome System Dysfunction in Alzheimer's 80%
see_also📖Probiotics in Mild Alzheimer's Disease (NCT06181513)80%
see_also📖Masupirdine for Agitation in Alzheimer's Disease (NCT0580%
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see_also📖BMS-986446 Phase 2 Trial for Early Alzheimer's Disease80%
see_also📖Tear Film Biomarkers in Alzheimer's Disease80%
see_also📖TRAILBLAZER-ALZ 3 (NCT05026866) — Donanemab for Preclinical 80%
see_also📖VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers80%
see_also📖NLRP3 Inflammasome Pathway in Alzheimer's Disease80%
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related🧪Trans-Synaptic Adhesion Molecule Modulation80%
see_also📖A Phase 3, Randomised, Double-blinded, Placebo-controlled St80%
see_also📖Metal Ion Homeostasis in Alzheimer's Disease80%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy80%
see_also📖Sleep Biomarkers for Alzheimer's Disease80%
see_also📖Sleep and Circadian Dysfunction in Alzheimer's Disease80%
see_also📖VY7523 Phase 1/2 Alzheimer's Disease Trial80%
see_also📖NCT07477431 - Levetiracetam for Persons at Risk for Alzheime80%
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see_also📖Mitochondrial Dysfunction in Alzheimer's Disease Pathwa80%
related🧪APOE Isoform Expression Across Glial Subtypes80%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK80%
related🧪TREM2-mediated microglial tau clearance enhancement80%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia80%
see_also📖Siponimod for Alzheimer's Disease (NCT06639282)80%
see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh80%
see_also📖GV1001 for Moderate to Severe Alzheimer's Disease (NCT080%
see_also📖GSK4527226 (AL101) for Early Alzheimer's Disease (NCT0680%
see_also📖Neuroinflammation in Alzheimer's Disease80%
see_also📖NCT06803823 - ONO-2020 for Agitation in Alzheimer's Dis80%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro80%
see_also📖Exciva Alzheimer's Disease Phase 2/3 Trial80%
related🧪HSP90-Tau Disaggregation Complex Enhancement80%
see_also📖Centella asiatica Phase 1 Trial for Alzheimer's Disease80%
related🧪Synaptic Vesicle Tau Capture Inhibition80%
see_also📖EEG Microstates in Alzheimer's Disease80%
see_also📖Vascular Dementia Mechanisms — Overlap with Alzheimer's80%
see_also📖Guanfacine NorAD - Phase 3 Trial for Alzheimer's Diseas80%
related🧪Complement C1QA Spatial Gradient in Cortical Layers80%
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see_also📖ONO-2020 for Alzheimer's Disease (NCT06881836)80%
see_also📖IGC-AD1 for Agitation in Alzheimer's Disease (NCT05543680%
see_also📖SToP-AD: Suvorexant for Alzheimer's Disease Prevention80%
see_also📖APOE Lipid Metabolism Pathway in Alzheimer's Disease80%
see_also📖Synaptic Biomarkers for Alzheimer's Disease80%
see_also📖Escitalopram for Agitation in Alzheimer's Disease (NCT080%
see_also📖Senicapoc Alzheimer's Disease Trial - NCT0480424180%
see_also📖Piromelatine 20 mg for Mild Dementia Due to Alzheimer's80%
see_also📖CD33 Siglec Receptor Dysfunction Alzheimer's Disease Ca80%
see_also📖NCT03875638 - Levetiracetam for Alzheimer's Disease80%
see_also📖CBD (Cannabidiol) for Alzheimer's Disease Agitation - N80%
see_also📖Synaptic Therapy Alzheimer's Research Trial (START): A 80%
see_also📖Sporadic Alzheimer's Disease Pathway80%
see_also📖SNIFF-Combo: Intranasal Insulin + Empagliflozin for Alzheime80%
see_also📖Cannabidiol for Alzheimer's Disease Prevention (NCT058280%
see_also📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di80%
see_also📖Recombinant Human Serum Albumin for Alzheimer's Disease80%
see_also📖LHP588: P. gingivalis Targeting for Alzheimer's Disease80%
related🧪VCP-Mediated Autophagy Enhancement80%
see_also📖Master Screening Study to Determine Individuals With Potenti80%
see_also📖Neurovascular Dysfunction in Alzheimer's Disease: Integ80%
see_also📖ITI-1284 for Alzheimer's Disease Psychosis (NCT0654083380%
see_also📖Neuroinflammation Hypothesis in Alzheimer's Disease80%
related🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation80%
see_also📖KarXT (Xanomeline/Trospium) - Phase 3 for Alzheimer's D80%
see_also📖KarXT for Alzheimer's Disease Cognitive Impairment - MI80%
see_also📖TRAP-AD: Transcranial Photobiomodulation for Alzheimer'80%
see_also📖Eye-Tracking Digital Markers in Alzheimer's Disease80%
see_also📖Novartis Alzheimer's Disease Phase 2 Trial (NCT0709451680%
see_also📖DTI Biomarkers for Alzheimer's Disease80%
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see_also📖NPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease80%
see_also📖Neurogranin - Alzheimer's Disease Biomarker80%
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see_also📖Diffuse Amyloid Deposits in Alzheimer's Disease80%
see_also📖Biogen Alzheimer's Disease Phase 2 Trial (NCT05399888)80%
see_also📖EEG Biomarkers for Alzheimer's Disease80%
related🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli80%
see_also📖Sex-Specific Mechanisms in Alzheimer's Disease80%
see_also📖Masupirdine for Alzheimer's Disease Agitation80%
see_also📖KarXT for Alzheimer's Disease Cognitive Impairment - MI80%
see_also📖PLX5622 CSF1R Inhibitor Trial in Early Alzheimer's Dise80%
see_also📖DMB-I (Latrepirdine) Phase 3 (NCT07251023) — Alzheimer'80%
see_also📖GFAP in Alzheimer's Disease80%
see_also📖Olfactory Biomarkers for Alzheimer's Disease80%
see_also📖Speech and Cognitive Biomarkers for Alzheimer's Disease80%
see_also📖Endolysosomal Pathway in Alzheimer's Disease80%
see_also📖Plasma Phospho-Tau Ratio Diagnostic Panel for Alzheimer'80%
see_also📖MK-2214 for Early Alzheimer's Disease80%
see_also📖NAB-IT: Nabilone for Agitation in Alzheimer's Disease80%
related🧪Complement C1QA Spatial Gradient in Cortical Layers72%
related🧪APOE Isoform Expression Across Glial Subtypes72%
related🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli72%
related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation72%
related🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation72%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK72%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia72%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro72%
related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%
related🧫Animal Model Comparison for Neurodegenerative Disease Therap70%
related🧫Experiment Validation: In vitro ThT Assay70%
related🧫Regulated Necrosis Validation Study in Parkinson's Dise70%
related🧫Endocannabinoid System Dysfunction Validation in Parkinson&#70%
related🧫Experiment Validation: In vitro ThT Assay70%
related🧫Neural Oscillation Dysfunction Validation in Parkinson'70%
related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
related🧫Regulated Necrosis Validation Study in Parkinson's Dise70%
related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%
related🧫Stress Granule Dysfunction Validation in Parkinson's Di70%
related🧫Neural Oscillation Dysfunction Validation in Parkinson'70%
related🧫Protein Aggregation Kinetic Validation Results70%
related🧫Oligodendrocyte-Myelin Dysfunction Validation in Parkinson&#70%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
related🧫Glymphatic-Circadian Axis Enhancement Therapy for Parkinson&70%
related🧫Protein Aggregation Kinetic Validation Results70%
related🧫Oligodendrocyte-Myelin Dysfunction Validation in Parkinson&#70%
related🧫Glymphatic-Circadian Axis Enhancement Therapy for Parkinson&70%
related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%
related🧫Stress Granule Dysfunction Validation in Parkinson's Di70%
related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%
related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%
related🧫Animal Model Comparison for Neurodegenerative Disease Therap70%
related🧫Endocannabinoid System Dysfunction Validation in Parkinson&#70%
related🧫Gap Junction Dysfunction Validation in Parkinson's Dise60%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD60%
related🧫Tau ASO Therapy60%
related🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti60%
related🧫Viral Infections and Alzheimer's Disease — causal mecha60%
related🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 60%
related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi60%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD60%
related🧫Microglial TREM2 Agonist In Vivo Efficacy60%
related🧫Traumatic Brain Injury and Alzheimer's Disease Relation60%
related🧫Mixed Pathology Effects on Parkinson's Disease Progress60%
related🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease60%
related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#60%
related🧫Sleep Disruption and Alzheimer's Disease — mechanism an60%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 60%
related🧫Vascular Contribution to Alzheimer's Disease — Beyond A60%
related🧫4R-Tau Targeting Therapies for PSP and CBS60%
related🧫Down Syndrome Alzheimer's Disease: Mechanisms and Thera60%
related🧫Microbiome-Gut-Brain Axis in Alzheimer's Disease — mech60%
related🧫Vascular Contributions to Alzheimer Disease and Mixed Pathol60%
related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau60%
related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#60%
related🧫Experiment: Autoimmune Hypothesis Testing in AD60%
related🧫Cholinergic System Dysfunction in DLB — Mechanisms and Thera60%
related🧫s:** - Test whether HCN1 knockout specifically in EC layer I60%
related🧫ApoE4 Function in Alzheimer's Disease60%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 60%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr60%
related🧫Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?60%
related🧫TREM2 Function in Alzheimer's Disease — From Risk Varia60%
related🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M60%
related🧫Lifestyle Intervention Mechanisms in Alzheimer's Diseas60%
related🧫Migraine Cortical Hyperexcitability and Alzheimer's Dis60%
related🧫Prion Strain Diversity and Selective Vulnerability60%
related🧫tACS Connectivity Trial in Early Alzheimer's60%
related🧫Blood-Based Biomarker Panel for Early AD Detection60%
related🧫Normal Aging to Alzheimer's Disease Transition Trigger 60%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration60%
related🧫Anti-Tau Immunotherapy Dosing Optimization60%
related🧫FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation60%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise60%
related🧫Sex Differences in Alzheimer's Disease — mechanisms and60%
related🧫Proposed experiment from debate on Synaptic pruning by micro60%
related🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa60%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease60%
related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi54%
related🧫Prion Strain Diversity and Selective Vulnerability54%
related🧫s:** - Test whether HCN1 knockout specifically in EC layer I54%
related🧫Vascular Contribution to Alzheimer's Disease — Beyond A54%
related🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti54%
related🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M54%
related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#54%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease54%
related🧫Viral Infections and Alzheimer's Disease — causal mecha54%
related🧫Microglial TREM2 Agonist In Vivo Efficacy54%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 54%
related🧫Vascular Contributions to Alzheimer Disease and Mixed Pathol54%
related🧫ApoE4 Function in Alzheimer's Disease54%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr54%
related🧫Down Syndrome Alzheimer's Disease: Mechanisms and Thera54%
related🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease54%
related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau54%
related🧫tACS Connectivity Trial in Early Alzheimer's54%
related🧫Migraine Cortical Hyperexcitability and Alzheimer's Dis54%
related🧫Anti-Tau Immunotherapy Dosing Optimization54%
related🧫Proposed experiment from debate on Synaptic pruning by micro54%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration54%
related🧫4R-Tau Targeting Therapies for PSP and CBS54%
related🧫Sex Differences in Alzheimer's Disease — mechanisms and54%
related🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 54%
related🧫Blood-Based Biomarker Panel for Early AD Detection54%
related🧫Traumatic Brain Injury and Alzheimer's Disease Relation54%
related🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa54%
related🧫Mixed Pathology Effects on Parkinson's Disease Progress54%
related🧫Gap Junction Dysfunction Validation in Parkinson's Dise54%
related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#54%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise54%
related🧫Sleep Disruption and Alzheimer's Disease — mechanism an54%
related🧫Cholinergic System Dysfunction in DLB — Mechanisms and Thera54%
related🧫Tau ASO Therapy54%
related🧫Microbiome-Gut-Brain Axis in Alzheimer's Disease — mech54%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 54%
related🧫TREM2 Function in Alzheimer's Disease — From Risk Varia54%
related🧫Normal Aging to Alzheimer's Disease Transition Trigger 54%
related🧫FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation54%
related🧫Experiment: Autoimmune Hypothesis Testing in AD54%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD54%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD54%
related🧫Lifestyle Intervention Mechanisms in Alzheimer's Diseas54%
related🧫Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?54%
related🔬The disease-associated microglia (DAM) phenotype involves TR50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬Astrocytes adopt A1 (neurotoxic) and A2 (neuroprotective) ph50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬What are the most promising therapeutic strategies for targe50%
mentions🧪Gamma entrainment therapy to restore hippocampal-cortical sy50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪Prefrontal sensory gating circuit restoration via PV interne50%
mentions🧪Trans-Synaptic Adhesion Molecule Modulation50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪Extracellular Vesicle Biogenesis Modulation50%
related🔬Can gut-brain axis modulation prevent or slow Alzheimer'50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Comprehensive analysis of immune cell subtypes in neurodegen50%
related🔬How to break the GBA-alpha-synuclein bidirectional loop for 50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
mentions🧪Synaptic Vesicle Tau Capture Inhibition50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬What cell types are most vulnerable in Alzheimers Disease ba50%
mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%
related🔬Is disrupted sleep a cause or consequence of neurodegenerati50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🔬What cell types are most vulnerable in Alzheimer's Dise50%
mentions🔬The disease-associated microglia (DAM) phenotype involves TR40%
mentions🔬Can gut-brain axis modulation prevent or slow Alzheimer'40%
mentions🔬Is disrupted sleep a cause or consequence of neurodegenerati40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
related🧪Prefrontal sensory gating circuit restoration via PV interne40%
mentions🔬What are the most promising therapeutic strategies for targe40%
mentions🔬Astrocytes adopt A1 (neurotoxic) and A2 (neuroprotective) ph40%
related🧪LRP1-Dependent Tau Uptake Disruption40%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy40%
mentions🔬What are the mechanisms underlying what are the mechanisms b40%
related🧪Trans-Synaptic Adhesion Molecule Modulation40%
mentions🔬What cell types are most vulnerable in Alzheimers Disease ba40%
mentions🔬How to break the GBA-alpha-synuclein bidirectional loop for 40%
related🧪VCP-Mediated Autophagy Enhancement40%
mentions🔬What cell types are most vulnerable in Alzheimer's Dise40%
related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna40%
mentions🔬Comprehensive analysis of immune cell subtypes in neurodegen40%
related🧪HSP90-Tau Disaggregation Complex Enhancement40%
related🧪Extracellular Vesicle Biogenesis Modulation40%
related🧪Synaptic Vesicle Tau Capture Inhibition40%

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