🧫

4R-Tau Targeting Therapies for PSP and CBS

active

experiment Created: 2026-04-02T17:01:41 By: crosslink-v2 Quality: 67% ✓ SciDEX ID: experiment-exp-wiki-experiments-4r-tau-t

🧫 Experiment Protocol Clinical

🧫 View Full Experiment Page →

Metadata

source	{'type': 'manual', 'source_name': 'wiki', 'extracted_by': 'backfill_v1', 'extraction_date': '2026-04-16T01:00:16.899795Z'}
summary	# 4R-Tau Targeting Therapies for PSP and CBS ## Background and Rationale This Phase II randomized, double-blind, placebo-controlled clinical trial investigates isoform-selective 4R-tau targeting thera
entities	{'genes': ['PSP'], 'diseases': ["Alzheimer's Disease"]}
model_system	human
experiment_type	clinical
primary_outcome	Validate 4R-Tau Targeting Therapies for PSP and CBS
methodology_notes	Phase 1 (Weeks 0-4): Screen 300 participants with probable PSP (MDS-PSP criteria) or CBS (Armstrong criteria) aged 40-80. Conduct comprehensive baseline assessments including neuropsychological batter
replication_status	conflicting
extraction_metadata	{'backfill_at': '2026-04-16T01:00:16.899800', 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'extraction_confidence': 0.4}

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

1080

Outgoing

934

0 supporting 0 contradicting 0 neutral

View full evidence profile →