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Gap Junction Dysfunction Validation in Parkinson's Disease

experiment Created: 2026-04-02T17:01:41 By: crosslink-v2 Quality: 67% ✓ SciDEX ID: experiment-exp-wiki-experiments-gap-junc
🌍 Provenance Graph 9 nodes, 30 edges

derives from (16)

▸ Show 11 more

supports (5)

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
568
Outgoing
520
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (1086)
mentions📖GAP43100%
mentions📖RAB27A100%
experiment_target📖GAP43100%
mentions📖GJA1100%
mentions📖alzheimers-disease97%
derives_from📖Gap Junction Dysfunction Validation in Parkinson's Dise95%
experiment_target🧪CX43 hemichannel engineering enables size-selective mitochon90%
derives_from🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m90%
experiment_target🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho90%
experiment_target🧪GAP43-mediated tunneling nanotube stabilization enhances neu90%
derives_from🧪CX43 hemichannel engineering enables size-selective mitochon90%
derives_from🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho90%
derives_from🧪RAB27A-dependent extracellular vesicle engineering for mitoc90%
experiment_target🧪RAB27A-dependent extracellular vesicle engineering for mitoc90%
experiment_target🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m90%
derives_from🧪GAP43-mediated tunneling nanotube stabilization enhances neu90%
related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m85%
related🧪CX43 hemichannel engineering enables size-selective mitochon85%
related🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho85%
related🧪RAB27A-dependent extracellular vesicle engineering for mitoc85%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu85%
mentions📖GAP43 Protein80%
supports🧪GAP43-mediated tunneling nanotube stabilization enhances neu80%
supports🧪RAB27A-dependent extracellular vesicle engineering for mitoc80%
supports🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m80%
supports🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho80%
supports🧪CX43 hemichannel engineering enables size-selective mitochon80%
mentions📖CD68 Protein (Macrosialin)70%
mentions📖SNCA-A53T Alpha-Synuclein Neurons70%
mentions📖PARK7 (DJ-1) Protein70%
mentions📖CSF and Blood Biomarkers in Progressive Supranuclear Palsy70%
mentions📖MRI for Neurodegenerative Diseases70%
mentions📖CSF-1R Inhibitors70%
mentions📖Purinergic Receptor P2X 7 (P2X7)70%
mentions📖P2X7 Protein70%
mentions📖TNF Alpha Protein70%
mentions📖csf-pta18170%
mentions📖p2x7-receptor-neurons70%
mentions📖TNF Signaling Pathway in Neurodegeneration70%
related📖RAB27A Protein (Ras-Related Protein Rab-27A)70%
mentions📖CSF Biomarker Comparison Across Neurodegenerative Diseases70%
related📖Alzheimer's Disease70%
mentions📖CSF O-GlcNAc — Target Engagement Biomarker for OGA Inhibitor70%
mentions📖p2x770%
mentions📖RAB27A Protein (Ras-Related Protein Rab-27A)70%
mentions📖ATP P2X3 Receptor Neurons70%
mentions📖PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Diseas70%
mentions📖SNCA-Overexpressing Dopaminergic Neurons70%
mentions📖PANX1 Gene70%
related📖GAP43 Gene70%
related📖RAB27A Gene70%
mentions📖TNF Gene70%
mentions📖CSF Dynamics and Glymphatic Therapy in CBS/PSP70%
related📖GAP43 Protein70%
mentions📖SNCA Gene Variants and Mutations70%
mentions📖GJA1 Protein70%
related📖RAB27A Protein (Ras-Related Protein Rab-27A)70%
related📖GAP43 Protein70%
mentions📖PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease70%
mentions📖CSF Neurofilament Light Chain (NfL) in Neurodegeneration70%
mentions📖PARK7 Gene - DJ-1/PARK770%
mentions📖PET Imaging Combined with Fluid Biomarkers70%
mentions📖PANX1 Protein70%
mentions📖CSF and Blood Biomarkers in Progressive Supranuclear Palsy70%
mentions📖PARK7 — Parkinsonism Associated Deglycase (DJ-1)70%
mentions📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi70%
mentions📖GAP43 Gene70%
mentions📖CSF Cytokine Profiles as Parkinson's Disease Biomarkers70%
mentions📖DAT Protein70%
mentions📖PET Imaging in Neurodegeneration70%
mentions📖P2X7 Receptor Antagonists for Neurodegeneration70%
mentions📖P2X7 Receptor Modulation Therapy70%
mentions📖TNF-alpha Protein - Tumor Necrosis Factor70%
mentions📖P2X7 Receptor Antagonists for Parkinson's Disease70%
related📖GJA170%
mentions📖snca-protein70%
mentions📖MRI Atrophy Patterns in CBS/PSP70%
mentions📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain70%
mentions📖PRKN — Parkin RBR E3 Ubiquitin Protein Ligase70%
mentions📖CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 70%
mentions📖SNCA A53T70%
mentions📖park770%
mentions📖CSF Synaptic Biomarker Panel for Neurodegenerative Diseases70%
mentions📖GJA170%
mentions📖DAT Scan Imaging70%
related📖GJA1 Protein70%
mentions📖CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 70%
mentions📖RAB27A Gene70%
mentions📖entities-tnf70%
mentions📖TNF - Tumor Necrosis Factor70%
mentions📖CSF Biomarkers for Corticobasal Syndrome and Progressive Sup70%
mentions📖PET Imaging for Neurodegenerative Diseases70%
mentions📖P2X7 Receptor Protein70%
mentions📖MRI and Imaging Findings in Corticobasal Syndrome70%
mentions📖P2Y Purinergic Receptor Neurons70%
mentions📖SNCA — Alpha-Synuclein70%
mentions📖PARK7 Protein (DJ-1)70%
mentions📖SNCA — Alpha-Synuclein Gene Entity Page70%
related📖entities-tnf63%
related📖SNCA-Overexpressing Dopaminergic Neurons63%
related📖PRKN — Parkin RBR E3 Ubiquitin Protein Ligase63%
related📖SNCA-A53T Alpha-Synuclein Neurons63%
related📖park763%
related📖SNCA Gene Variants and Mutations63%
related📖CSF Neurofilament Light Chain (NfL) in Neurodegeneration63%
related📖CD68 Protein (Macrosialin)63%
related📖GJA163%
related📖SNCA — Alpha-Synuclein63%
related📖TNF - Tumor Necrosis Factor63%
related📖PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Diseas63%
related📖PET Imaging for Neurodegenerative Diseases63%
related📖CSF Biomarker Comparison Across Neurodegenerative Diseases63%
related📖MRI for Neurodegenerative Diseases63%
related📖P2X7 Receptor Antagonists for Parkinson's Disease63%
related📖PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease63%
related📖PARK7 — Parkinsonism Associated Deglycase (DJ-1)63%
related📖CSF Dynamics and Glymphatic Therapy in CBS/PSP63%
related📖P2Y Purinergic Receptor Neurons63%
related📖ATP P2X3 Receptor Neurons63%
related📖p2x7-receptor-neurons63%
related📖CSF and Blood Biomarkers in Progressive Supranuclear Palsy63%
related📖P2X7 Receptor Protein63%
related📖CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 63%
related📖DAT Scan Imaging63%
related📖PARK7 Gene - DJ-1/PARK763%
related📖TNF Gene63%
related📖CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 63%
related📖RAB27A Gene63%
related📖GJA1 Protein63%
related📖CSF Biomarkers for Corticobasal Syndrome and Progressive Sup63%
related📖PANX1 Protein63%
related📖CSF O-GlcNAc — Target Engagement Biomarker for OGA Inhibitor63%
related📖PET Imaging Combined with Fluid Biomarkers63%
related📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain63%
related📖GAP43 Gene63%
related📖CSF-1R Inhibitors63%
related📖TNF-alpha Protein - Tumor Necrosis Factor63%
related📖PANX1 Gene63%
related📖DAT Protein63%
related📖TNF Signaling Pathway in Neurodegeneration63%
related📖P2X7 Receptor Antagonists for Neurodegeneration63%
related📖snca-protein63%
related📖CSF and Blood Biomarkers in Progressive Supranuclear Palsy63%
related📖csf-pta18163%
related📖SNCA A53T63%
related📖PARK7 (DJ-1) Protein63%
related📖PET Imaging in Neurodegeneration63%
related📖MRI and Imaging Findings in Corticobasal Syndrome63%
related📖p2x763%
related📖P2X7 Receptor Modulation Therapy63%
related📖TNF Alpha Protein63%
related📖P2X7 Protein63%
related📖PARK7 Protein (DJ-1)63%
related📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi63%
related📖Purinergic Receptor P2X 7 (P2X7)63%
related📖MRI Atrophy Patterns in CBS/PSP63%
related📖CSF Synaptic Biomarker Panel for Neurodegenerative Diseases63%
related📖SNCA — Alpha-Synuclein Gene Entity Page63%
related📖CSF Cytokine Profiles as Parkinson's Disease Biomarkers63%
related📖CAR-A Therapy - Chimeric Antigen Receptor Astrocytes for Alz60%
related📖DNA Damage Response in Alzheimer's Disease60%
related📖Microglial State Trajectory from Mobilization to Dysregulati60%
related📖A Phase 3, Randomised, Double-blinded, Placebo-controlled St60%
mentions📖Parkin Protein60%
related📖Failed Alzheimer's Disease Clinical Trials Analysis60%
related📖NRTI Immunomodulation in Alzheimer's Disease: Molecular60%
related📖APOE4 and Alzheimer's Disease Risk60%
related📖MK-2214 for Early Alzheimer's Disease60%
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related📖Synaptic Dysfunction in Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease60%
related📖Cortical Layer 5 Pyramidal Neurons in Alzheimer's Disea60%
mentions📖gaps60%
related📖Eye-Tracking Digital Markers in Alzheimer's Disease60%
related📖Nucleus Basalis Cholinergic Neurons in Alzheimer's Dise60%
related📖Neurofibrillary Tangle Propagation in Alzheimer's Disea60%
related📖Cortical Interneurons in Alzheimer's Disease60%
related📖Calcium Signaling Dysregulation in Alzheimer's Disease60%
related📖Digital Biomarkers for Alzheimer's Disease60%
related📖GSK4527226 (AL101) for Early Alzheimer's Disease (NCT0660%
related📖Normal Aging to Alzheimer's Disease Transition Trigger 60%
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related📖Glymphatic System in Alzheimer's Disease60%
related📖ONO-2020 for Alzheimer's Disease (NCT06881836)60%
related📖Locus Coeruleus Degeneration Hypothesis in Alzheimer's 60%
related📖Bumetanide — Alzheimer's Disease60%
mentions📖alpha-synuclein60%
related📖SYK Kinase in Microglial Activation and Alzheimer's Dis60%
related📖Multimodal AI Forecasting for Alzheimer's Disease Progr60%
related📖Alzheimer's Disease vs Parkinson's Disease Compari60%
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related📖Nucleus Basalis of Meynert in Alzheimer's Disease60%
related📖SHR-1707 for Alzheimer's Disease (NCT06199037)60%
mentions📖therapeutics60%
related📖PLX5622 CSF1R Inhibitor Trial in Early Alzheimer's Dise60%
related📖Prefrontal Cortex Neurons in Alzheimer's Disease60%
related📖Mitochondrial Dysfunction in Alzheimer's Disease Pathwa60%
related📖Lifestyle Intervention Mechanisms in Alzheimer's Diseas60%
related📖Alzheimer's Disease Pyroptosis and Gasdermin Inhibitor 60%
related📖Nanomedicine for Alzheimer's Disease60%
related📖Early-Onset Alzheimer's Disease (EOAD)60%
related📖Anti-Amyloid Immunotherapy Comparison Matrix for Alzheimer&#60%
related📖AMDX-2011P Phase 2 Trial for Alzheimer's Disease60%
related📖Neuronal Death Pathways in Alzheimer's Disease60%
mentions📖neuroimaging60%
mentions📖events60%
related📖Alzheimer's Disease Apolipoprotein and Lipid Transport 60%
related📖Parvalbumin-Positive Interneurons in Alzheimer's Diseas60%
related📖AMDX-2011P Retinal Amyloid Tracer in Alzheimer's Diseas60%
related📖Geniposide for Alzheimer's disease - immune biomarker t60%
related📖Basal Forebrain Cholinergic Neurons in Alzheimer's Dise60%
related📖Horizontal Cells in Alzheimer's Disease60%
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related📖APP Mutations in Alzheimer's Disease60%
related📖ITI-1284 for Alzheimer's Disease Psychosis (NCT0654083360%
related📖Alzheimer's Disease Neuropathology is Defined by the Ac60%
related📖TREM2 Variants in Alzheimer's Disease60%
related📖Innate Immune Signaling Pathways in Alzheimer's Disease60%
related📖Circadian Rhythm Dysfunction in Alzheimer's Disease60%
related📖Epigenetic Alterations in Alzheimer's Disease60%
related📖Alzheimer's Disease DNA Damage Repair and Chromatin Rem60%
related📖TREM2 Microglia Pathway in Alzheimer's Disease60%
related📖Cholinergic Basal Forebrain Neurons in Alzheimer's Dise60%
related📖Probiotics in Mild Alzheimer's Disease (NCT06181513)60%
related📖Nucleus Basalis of Meynert Cholinergic Neurons in Alzheimer&60%
related📖ASL Perfusion Biomarkers for Alzheimer's Disease60%
related📖LY-3372689 MAGNOLIA Trial - Phase 2 in Alzheimer's Dise60%
related📖TREM2 Function in Alzheimer's Disease — From Risk Varia60%
related📖Alzheimer's Disease Research Centers (ADRC) Program60%
related📖Enteric Neurons in Alzheimer's Disease60%
related📖VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers60%
related📖Hippocampal CA1 Pyramidal Neurons in Alzheimer's Diseas60%
related📖INPP5D SHIP1 Dysfunction Alzheimer's Disease Causal Cha60%
related📖Cannabidiol for Alzheimer's Disease Prevention (NCT058260%
related📖AAIC 2026: Combination Therapy and Multi-Target Approaches i60%
related📖Sporadic Alzheimer's Disease Pathway60%
related📖Hippocampal CA3 Pyramidal Neurons in Alzheimer's Diseas60%
related📖EX039 Phase 2 (NCT05413655) — Oral Therapeutic for Alzheimer60%
related📖Sex Differences in Alzheimer's Disease — mechanisms and60%
related📖Masupirdine for Alzheimer's Disease Agitation60%
related📖Alzheimer's Disease VEGF/Angiogenic Signaling and Cereb60%
related📖Microglia in Alzheimer's Disease Neurodegeneration60%
mentions📖experiments60%
related📖Vulnerable Hippocampal CA1 Pyramidal Neurons in Alzheimer&#x60%
related📖Microglia and neuroinflammation in Alzheimer's Disease60%
related📖Diffuse Amyloid Deposits in Alzheimer's Disease60%
related📖Alzheimer's Disease Neuropsychiatric and BPSD Treatment60%
related📖NRTIs for Alzheimer's Disease - Phase 1 (NCT07210528)60%
related📖Locus Coeruleus Noradrenergic Neurons in Alzheimer's Di60%
related📖Synaptic Biomarkers for Alzheimer's Disease60%
related📖Infectious Triggers in Alzheimer's Disease60%
mentions📖circuits60%
related📖Calcium Signaling Dysregulation in Alzheimer's Disease60%
related📖Exciva Alzheimer's Disease Phase 2/3 Trial60%
related📖Locus Coeruleus Neurons in Alzheimer's Disease60%
related📖Alzheimer's Disease Pathogenesis60%
related📖Alzheimer's Disease Neuroinflammation Companies60%
related📖Alzheimer's Disease Mitochondria-Targeting Companies60%
related📖Prodromal Alzheimer's Disease60%
related📖Autoimmune Hypothesis in Alzheimer's Disease60%
related📖Infectious Etiology Hypotheses in Alzheimer's Disease60%
related📖Neuroinflammation in Alzheimer's Disease60%
related📖Neuroinflammation and Microglia Pathway in Alzheimer's 60%
related📖CTAD 2026 — Clinical Trials on Alzheimer's Disease60%
related📖Microglia in Alzheimer's Disease Neurodegeneration60%
related📖Endolysosomal Pathway in Alzheimer's Disease60%
related📖RNA Metabolism Dysregulation in Alzheimer's Disease60%
related📖Alzheimer's disease pathology originates in the hippoca60%
related📖Senicapoc Alzheimer's Disease Trial - NCT0480424160%
related📖GFAP in Alzheimer's Disease60%
related📖Ferulic Acid Carbamate Derivatives for Alzheimer's Dise60%
related📖Ferroptosis Pathway in Alzheimer's Disease60%
related📖AAIC 2026: Cellular Pathophysiology and Neurodegeneration Bi60%
related📖Alzheimer's Disease Neuroimaging Initiative (ADNI)60%
related📖ApoE4 Function in Alzheimer's Disease60%
related📖Calcium Dysregulation in Alzheimer's Disease60%
related📖In Alzheimer's disease, biomarker events occur in a spe60%
related📖Locus Coeruleus Degeneration in Alzheimer's Disease60%
related📖ASN90 Phase 2 Trial - Early Alzheimer's Disease (NCT05660%
related📖Locus Coeruleus Noradrenergic Neurons in Alzheimer's Di60%
related📖GV1001 for Moderate to Severe Alzheimer's Disease (NCT060%
related📖Alzheimer's Disease Epigenetic Reader and BET Bromodoma60%
related📖Microglia in Alzheimer's Disease60%
mentions📖Dopaminergic Neurons60%
related📖Alzheimer's Disease Calcium Channel and Homeostasis The60%
related📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di60%
related📖Biogen Alzheimer's Disease Phase 2 Trial (NCT05399888)60%
related📖Neurovascular Dysfunction in Alzheimer's Disease: Integ60%
mentions📖Neuroinflammation Pathway60%
related📖Alzheimer's Disease Brain Banks and Tissue Repositories60%
related📖Alzheimer's Disease GABA Receptor and Excitotoxicity Th60%
related📖Tau Immunotherapy for Alzheimer's Disease60%
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related📖Cortical Neurons in Alzheimer's Disease54%
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related📖DLB, PDD, and Alzheimer's Disease: Cross-Disease Compar54%
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related📖Basal Forebrain Cholinergic Neurons in Alzheimer's Dise54%
related📖Cholinergic Basal Forebrain Neurons in Alzheimer's Dise54%
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mentions📖park750%
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mentions📖Enteric Glial Cells in Neurodegeneration44%
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mentions📖Alzheimer's Disease40%

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