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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

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paper Created: 2026-04-03T14:10:32 By: crosslink_script Quality: 95% 🔗 External ID: paper-33031745

🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile

Evidence Balance

+0%

Certainty

35%

Debates

0

Incoming

7

Outgoing

0

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (7)

derives_from🧫TDP-43 mitochondrial invasion and DNA release via mPTP100%

derives_from🧫TDP-43 mutant mouse model cGAS/STING pathway analysis100%

derives_from🧫cGAMP biomarker analysis in ALS patient spinal cord samples100%

derives_from🧫cGAS/STING pathway activation by TDP-43-released mtDNA100%

derives_from🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto100%

derives_from🧫cGAMP biomarker analysis in ALS patient spinal cord samples100%

derives_from🧫cGAS/STING pathway validation in TDP-43 mutant mice100%

💬 Discussion