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cGAS/STING pathway activation by TDP-43-released mtDNA

active
experiment Created: 2026-04-06T19:28:36 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-d081efb0-0d00-49ff-80b2-4
Related Entities
CGAS
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
116
Outgoing
111
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (225)
derives_from📄TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activa100%
mentions📖cGAS-STING Pathway Dysregulation Hypothesis in Parkinson90%
mentions📖CGAS Gene80%
related📖CGAS Gene72%
mentions📖ALS Therapeutic Landscape — Programs by Phase and Modality70%
mentions📖ALS Biomarkers and Disease Monitoring70%
mentions📖ALS Knowledge Gaps Ranked List70%
mentions📖proteins-tar-db-protein70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖gaps-als-regional-onset-spread70%
mentions📖ALS Cure Roadmap70%
related📖diseases-amyotrophic-lateral-sclerosis70%
mentions📖ALS Progression Trajectories70%
mentions📖ALS Mechanistic Pathway70%
mentions📖cell-types-tdp-43-proteinopathy-neurons70%
mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖TDP-43 Aggregate Neurons70%
mentions📖ALS Treatment Strategies70%
mentions📖ALS vs FTD: Comparative Investment Analysis70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Failed Approaches Analysis70%
mentions📖ALS Progression Rate Heterogeneity70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response in Neurons70%
mentions📖ALS-FTD Spectrum70%
mentions📖DNA Methylation70%
mentions📖TDP-43 Proteinopathy70%
mentions📖TDP-43 Protein70%
mentions📖ALS Combination Therapy Matrix70%
mentions📖AMP-PD: Accelerating Medicines Partnership: Parkinson's70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖STING Protein70%
mentions📖TDP-43 Pathology Reversibility in ALS70%
mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease70%
mentions📖proteins-sting-protein70%
mentions📖gaps-als-motor-neuron-vulnerability70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖gaps-tdp-43-pet-ligand-ftd70%
mentions📖dna-damage-repair70%
mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%
mentions📖ALS Pipeline Companies70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖ALS Trial Failure Analysis70%
mentions📖ALS Therapeutics70%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖ALS-FTD Overlap Neurons70%
mentions📖DNA Ligase IV Protein70%
mentions📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms70%
mentions📖ALS-FTD-Parkinsonism Comparison Matrix70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖ALS Clinical Trials Consortium (NEALS)70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖tdp-43-fus-rna-proteinopathy-comparison70%
mentions📖ALS Treatment Overview70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖ALS Regional Onset and Spread: Network-Level Staging Model70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖gaps-als70%
mentions📖ALS-FTD Overlap: Mechanistic Pathways70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖proteins-tdp43_protein70%
mentions📖ALS Therapeutic Scorecard70%
mentions📖TDP-43 Proteinopathy Investment Landscape70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖ALS Association70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖STING Gene70%
mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%
mentions📖gaps-als-progression-rate-heterogeneity70%
mentions📖ALS Biomarker-to-Mechanism Mapping70%
mentions📖TDP-43 RNA Granule Pathway70%
mentions📖ALS Disease Spectrum vs Molecular Subtypes70%
mentions📖ALS RNA Metabolism and Proteostasis Failure70%
mentions📖gaps-als-immune-signature-stratification70%
mentions📖STING Inhibitor Therapy in Neurodegeneration70%
mentions📖TDP-43 Proteinopathy in ALS70%
mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖TDP-43 Protein70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖ALS Pipeline70%
mentions📖TDP-43 Proteinopathy Neurons70%
mentions📖ALS Communication Brain-Computer Interfaces70%
mentions📖TDP-43 Splicing Modulation Therapy70%
mentions📖ALS Progression Rate Heterogeneity — mechanism and biomarker70%
mentions📖ALS Trial Failures Knowledge Gap70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 PET Ligand Development for FTD and ALS70%
mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%
mentions📖DNA Ligase III Protein70%
related📖STING Gene63%
related📖ALS Therapeutic Scorecard63%
related📖ALS Biomarker-to-Mechanism Mapping63%
related📖ALS Communication Brain-Computer Interfaces63%
related📖TDP-43 Proteinopathy Investment Landscape63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖TDP-43 Co-pathology in Corticobasal Syndrome63%
related📖proteins-tdp43_protein63%
related📖proteins-sting-protein63%
related📖ALS Clinical Trials Consortium (NEALS)63%
related📖ALS Trial Failures Knowledge Gap63%
related📖TDP-43 Protein63%
related📖ALS-FTD Overlap Neurons63%
related📖TDP-43 Protein63%
related📖DNA Ligase III Protein63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖ALS Treatment Overview63%
related📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker63%
related📖gaps-als-progression-rate-heterogeneity63%
related📖ALS Treatment Strategies63%
related📖TDP-43 Splicing Modulation Therapy63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖gaps-als-immune-signature-stratification63%
related📖gaps-tdp-43-pet-ligand-ftd63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖TDP-43 Proteinopathy Neurons63%
related📖ALS Biomarkers and Disease Monitoring63%
related📖TDP-43 Aggregate Neurons63%
related📖TDP-43 Pathology Reversibility in ALS63%
related📖cell-types-tdp-43-proteinopathy-neurons63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Damage Response Impairment Pathway63%
related📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms63%
related📖STING Inhibitor Therapy in Neurodegeneration63%
related📖ALS Progression Trajectories63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖TDP-43 Proteinopathy63%
related📖DNA Methylation in Neurodegeneration63%
related📖gaps-als63%
related📖STING Protein63%
related📖ALS Disease Spectrum vs Molecular Subtypes63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 RNA Granule Pathway63%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖ALS Combination Therapy Matrix63%
related📖tdp-43-fus-rna-proteinopathy-comparison63%
related📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio63%
related📖ALS-FTD Overlap: Mechanistic Pathways63%
related📖TDP-43 PET Ligand Development for FTD and ALS63%
related📖ALS Cure Roadmap63%
related📖TDP-43 DNA Repair Mechanism in ALS and Dementia63%
related📖ALS Progression Rate Heterogeneity — mechanism and biomarker63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖ALS Therapeutic Landscape — Programs by Phase and Modality63%
related📖ALS Cure Roadmap63%
related📖DNA Methylation63%
related📖ALS-FTD Spectrum63%
related📖ALS Therapeutics63%
related📖ALS Pipeline Companies63%
related📖proteins-tar-db-protein63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖gaps-als-regional-onset-spread63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖gaps-als-motor-neuron-vulnerability63%
related📖DNA Damage and Repair in Neurons63%
related📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖ALS Progression Rate Heterogeneity63%
related📖dna-damage-repair63%
related📖AMP-PD: Accelerating Medicines Partnership: Parkinson's63%
related📖ALS Mechanistic Pathway63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖ALS Failed Approaches Analysis63%
related📖ALS Regional Onset and Spread: Network-Level Staging Model63%
related📖ALS Knowledge Gaps Ranked List63%
related📖DNA Damage Repair Investment Landscape63%
related📖ALS-FTD-Parkinsonism Comparison Matrix63%
related📖ALS Pipeline63%
related📖ALS vs FTD: Comparative Investment Analysis63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖ALS Association63%
related📖DNA Ligase IV Protein63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖ALS Trial Failure Analysis63%
related📖ALS RNA Metabolism and Proteostasis Failure63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖TDP-43 Proteinopathy in ALS63%
related📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease63%
mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖neuroinflammation60%
mentions📖Mitochondria60%
mentions📖Bulbar Amyotrophic Lateral Sclerosis60%
mentions📖Amyotrophic Lateral Sclerosis (ALS)60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖Spinal Amyotrophic Lateral Sclerosis60%
mentions📖experiments60%
mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis60%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis54%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants54%
related📖Spinal Amyotrophic Lateral Sclerosis54%
related📖neuroinflammation54%
related📖experiments54%
related📖SOD1 Mutations in Amyotrophic Lateral Sclerosis54%
related📖Mitochondria54%
related📖Bulbar Amyotrophic Lateral Sclerosis54%
related📖Amyotrophic Lateral Sclerosis (ALS)54%
related📖FUS Mutations in Amyotrophic Lateral Sclerosis54%
mentions📖STING Gene50%
mentions📖Interferon Signaling in Neurodegeneration50%
mentions📖Enteroendocrine Cells44%
mentions📖HEK293 Cell Line44%
mentions📖Tumor Necrosis Factor (TNF)44%
mentions📖Glial Cells44%
mentions📖Neuroinflammation-Mitochondria Crosstalk Pathway44%

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