📄

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.

active

paper Created: 2026-04-03T14:10:32 By: crosslink_script Quality: 85% 🔗 External ID: paper-30335591

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

40%

Debates

0

Incoming

8

Outgoing

0

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (8)

derives_from🧫Trehalose-induced lysosomal changes and TFEB activation100%

derives_from🧫TFEB silencing and misfolded protein degradation100%

derives_from🧫Functional validation of trehalose effects on misfolded prot100%

derives_from🧫Trehalose analog testing for autophagy induction100%

derives_from🧫Trehalose-induced lysosomal membrane permeabilization and TF100%

derives_from🧫Gene expression analysis of autophagy targets following treh100%

derives_from🧫Trehalose-induced autophagy gene expression analysis100%

derives_from🧫PPP3/calcineurin-dependent TFEB dephosphorylation mechanism100%

💬 Discussion