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🧫

cGAMP biomarker analysis in ALS patient spinal cord samples

experiment Created: 2026-04-06T19:28:40 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-820a16b5-8133-478d-a80d-2
Related Entities
TARDBP
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
96
Outgoing
98
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (187)
related🧪Cryptic Exon Silencing Restoration100%
related🧪Glycine-Rich Domain Competitive Inhibition100%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding100%
related🧪Cross-Seeding Prevention Strategy100%
related🧫TDP-43 pathology prevalence and distribution in AD cases100%
derives_from📄TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activa100%
mentions📖TARDBP — TAR DNA Binding Protein 4390%
mentions📖tardbp80%
mentions📖TARDBP/TDP-43 Protein80%
mentions📖TARDBP — TAR DNA Binding Protein 4380%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%
related📖TARDBP/TDP-43 Protein72%
related📖TARDBP — TAR DNA Binding Protein 4372%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis72%
related📖tardbp72%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖ALS Therapeutic Landscape — Programs by Phase and Modality70%
mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease70%
mentions📖proteins-sting-protein70%
mentions📖ALS Pipeline Companies70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖ALS Mechanistic Pathway70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖ALS Trial Failure Analysis70%
mentions📖ALS Progression Rate Heterogeneity70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖ALS Biomarker-to-Mechanism Mapping70%
mentions📖ALS Combination Therapy Matrix70%
mentions📖AMP-PD: Accelerating Medicines Partnership: Parkinson's70%
mentions📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms70%
mentions📖dna-damage-repair70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖ALS-FTD Overlap Neurons70%
mentions📖ALS Treatment Overview70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖STING Gene70%
mentions📖ALS Regional Onset and Spread: Network-Level Staging Model70%
mentions📖ALS Therapeutics70%
mentions📖ALS Pipeline70%
mentions📖ALS-FTD-Parkinsonism Comparison Matrix70%
mentions📖ALS Therapeutic Scorecard70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖ALS-FTD Overlap: Mechanistic Pathways70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖gaps-als70%
mentions📖gaps-als-motor-neuron-vulnerability70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖gaps-als-progression-rate-heterogeneity70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖ALS Disease Spectrum vs Molecular Subtypes70%
mentions📖ALS RNA Metabolism and Proteostasis Failure70%
mentions📖gaps-als-immune-signature-stratification70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖ALS Clinical Trials Consortium (NEALS)70%
mentions📖ALS Biomarkers and Disease Monitoring70%
mentions📖gaps-als-regional-onset-spread70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
related📖diseases-amyotrophic-lateral-sclerosis70%
mentions📖ALS Progression Rate Heterogeneity — mechanism and biomarker70%
mentions📖ALS Trial Failures Knowledge Gap70%
mentions📖STING Inhibitor Therapy in Neurodegeneration70%
mentions📖DNA Ligase III Protein70%
mentions📖ALS Knowledge Gaps Ranked List70%
mentions📖ALS Association70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Progression Trajectories70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖STING Protein70%
mentions📖ALS Treatment Strategies70%
mentions📖ALS vs FTD: Comparative Investment Analysis70%
mentions📖DNA Methylation70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Failed Approaches Analysis70%
mentions📖ALS Communication Brain-Computer Interfaces70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response in Neurons70%
mentions📖ALS-FTD Spectrum70%
related📖STING Gene63%
related📖ALS Therapeutic Scorecard63%
related📖ALS Biomarker-to-Mechanism Mapping63%
related📖ALS Communication Brain-Computer Interfaces63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖proteins-sting-protein63%
related📖ALS Clinical Trials Consortium (NEALS)63%
related📖ALS Trial Failures Knowledge Gap63%
related📖ALS-FTD Overlap Neurons63%
related📖DNA Ligase III Protein63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖ALS Treatment Overview63%
related📖gaps-als-progression-rate-heterogeneity63%
related📖ALS Treatment Strategies63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖gaps-als-immune-signature-stratification63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖ALS Biomarkers and Disease Monitoring63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Damage Response Impairment Pathway63%
related📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms63%
related📖STING Inhibitor Therapy in Neurodegeneration63%
related📖ALS Progression Trajectories63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖gaps-als63%
related📖STING Protein63%
related📖ALS Disease Spectrum vs Molecular Subtypes63%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖ALS Combination Therapy Matrix63%
related📖ALS-FTD Overlap: Mechanistic Pathways63%
related📖ALS Cure Roadmap63%
related📖ALS Progression Rate Heterogeneity — mechanism and biomarker63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖ALS Therapeutic Landscape — Programs by Phase and Modality63%
related📖ALS Cure Roadmap63%
related📖DNA Methylation63%
related📖ALS-FTD Spectrum63%
related📖ALS Therapeutics63%
related📖ALS Pipeline Companies63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖gaps-als-regional-onset-spread63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖gaps-als-motor-neuron-vulnerability63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖ALS Progression Rate Heterogeneity63%
related📖dna-damage-repair63%
related📖AMP-PD: Accelerating Medicines Partnership: Parkinson's63%
related📖ALS Mechanistic Pathway63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖ALS Failed Approaches Analysis63%
related📖ALS Regional Onset and Spread: Network-Level Staging Model63%
related📖ALS Knowledge Gaps Ranked List63%
related📖DNA Damage Repair Investment Landscape63%
related📖ALS-FTD-Parkinsonism Comparison Matrix63%
related📖ALS Pipeline63%
related📖ALS vs FTD: Comparative Investment Analysis63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖ALS Association63%
related📖DNA Ligase IV Protein63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖ALS Trial Failure Analysis63%
related📖ALS RNA Metabolism and Proteostasis Failure63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease63%
mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%
related🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto60%
related📓Cryptic Exon Silencing Restoration -- Computational Analysis60%
related🧪Glycine-Rich Domain Competitive Inhibition60%
mentions📖Bulbar Amyotrophic Lateral Sclerosis60%
related🧫TDP-43 mutant mouse model cGAS/STING pathway analysis60%
related🧫Cognitive impact of TDP-43 pathology in AD patients60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding60%
mentions📖Spinal Amyotrophic Lateral Sclerosis60%
related🧫cGAS/STING pathway validation in TDP-43 mutant mice60%
related🧪Cross-Seeding Prevention Strategy60%
related🧪Cryptic Exon Silencing Restoration60%
related🧫TDP-43 mitochondrial invasion and DNA release via mPTP60%
mentions📖Amyotrophic Lateral Sclerosis (ALS)60%
mentions📖Mitochondria60%
related🧫TDP-43 pathology prevalence and distribution in AD cases60%
mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants54%
related📖SOD1 Mutations in Amyotrophic Lateral Sclerosis54%
related📖Spinal Amyotrophic Lateral Sclerosis54%
related📖Amyotrophic Lateral Sclerosis (ALS)54%
related📖FUS Mutations in Amyotrophic Lateral Sclerosis54%
related📖Bulbar Amyotrophic Lateral Sclerosis54%
related📖Mitochondria54%
mentions📖STING Gene50%

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