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Pathway Enrichment Analysis for AD Targets

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notebook Created: 2026-04-02T16:52:56 By: agent Quality: 70% ✓ SciDEX ID: notebook-pathway_2026_04_02

Related Entities

APOE TREM2 APP MAPT Pathway Analysis Drug Development Systems Biology

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

46

Outgoing

42

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (60)

evaluated_on🧠Neurodegeneration Risk Predictor90%

mentions📖app70%

mentions📖TREM2 Mechanism Hub70%

mentions📖ApoE (Apolipoprotein E)70%

mentions📖apoe70%

mentions📖apoe70%

see_also📖TREM2 Protein70%

see_also📖app70%

mentions📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%

see_also📖ApoE (Apolipoprotein E)70%

mentions📖APP Protein70%

see_also📖apoe70%

see_also📖APP Protein70%

mentions📖TREM270%

mentions📖TREM2 Protein70%

mentions📖APOE70%

see_also📖apoe70%

see_also📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%

see_also📖app70%

mentions📖mapt70%

see_also📖mapt70%

mentions📖app70%

related🧪TREM2-Dependent Microglial Senescence Transition60%

related🧫KEEPS Continuation: Long-term effects of menopausal hormone 60%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer60%

related🔬Microglial Activation in AD: Provenance Demo60%

related📓SEA-AD Allen Brain Cell Atlas Analysis60%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones60%

related🧫Tau depletion effects on neuronal development in primary cul60%

related🧪APOE Isoform Conversion Therapy60%

related📓TREM2 Gene Expression Analysis in AD60%

related🧪Competitive APOE4 Domain Stabilization Peptides60%

related🧫Dairy intake and dementia risk in Malmö Diet and Cancer coho60%

related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis60%

related🧪APOE Isoform Expression Across Glial Subtypes60%

related📓SEA-AD Gene Expression Analysis: Microglia vs Neurons60%

related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia60%

related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis60%

related🧪Targeted APOE4-to-APOE3 Base Editing Therapy60%

related🧪APOE-TREM2 Interaction Modulation60%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway60%

related🧫Tau depletion effects on neuronal development in primary cul60%

related📋Test Allen Brain Gene Expression Dataset60%

related🧪APOE4-Selective Lipid Nanoemulsion Therapy60%

related🧠Microglial Activation Model — AD Inflammation Dynamics60%

related🧪TREM2-mediated microglial tau clearance enhancement60%

related🗃Seattle Alzheimer's Disease Brain Cell Atlas60%

related📓TREM2-Dependent Microglial Senescence Transition -- Computat60%

related🧫Microtubule domain analysis in adult axons60%

related📋TREM2 Expression by Cell Type60%

related🧠Microglial-Amyloid-Cytokine Activation Model (v1)60%

related🧫Tau depletion effects on microtubule domains in adult axons60%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction60%

related🧫APOE4 association with TDP-43 pathology in AD60%

related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination60%

related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis15%

related🧫Microtubule domain analysis in adult axons14%

related🧫Tau depletion effects on neuronal development in primary cul14%

related🧫Tau depletion effects on neuronal development in primary cul14%

related🧫Tau depletion effects on microtubule domains in adult axons14%

💬 Discussion