concept

TMEM16F

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM16F: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

2Analyses

13Outgoing

3Incoming

0Experiments

2Debates

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💡 Concept Info

Name	TMEM16F
Key Genes/Proteins	ACSL4, Chac1, GPX4, NCX1, NRF2, PIEZO1
Related Diseases	phosphatidylserine externalization
Related Pathways	cytosolic calcium elevation

Pathway Diagram

graph TD
    TMEM16F[TMEM16F]
    TMEM16F -->|regulates| GPX4[GPX4]
    TMEM16F -->|regulates| SLC7A11[SLC7A11]
    TMEM16F -->|regulates| NRF2[NRF2]
    TMEM16F -->|regulates| ACSL4[ACSL4]
    TMEM16F -->|interacts| NCX1[NCX1]
    TMEM16F -->|regulates| Ptgs2[Ptgs2]
    TMEM16F -->|regulates| Chac1[Chac1]
    TMEM16F -->|regulates| Src[Src]
    TMEM16F -->|regulates| SLC3A2[SLC3A2]
    TMEM16F -->|regulates| VE_cadherin[VE-cadherin]
    PIEZO1[PIEZO1] -->|interacts| TMEM16F
    benchmark_ot_ad_answer_key_TME[benchmark_ot_ad_answer_key:TMEM16F] -->|data_in| TMEM16F

Outgoing (13)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TMEM16F	data_in	dataset_row	0.00
GPX4	regulates	gene	1.00
SLC7A11	regulates	gene	1.00
NRF2	regulates	gene	1.00
ACSL4	regulates	gene	1.00
NCX1	interacts_with	gene	1.00
Ptgs2	regulates	gene	1.00
Chac1	regulates	gene	1.00
Src	regulates	gene	1.00
SLC3A2	regulates	gene	1.00
VE-cadherin	regulates	protein	1.00
phosphatidylserine externalization	causes	phenotype	0.90
PS externalization	regulates	process	0.50

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TMEM16F	data_in	dataset_row	0.00
PIEZO1	interacts_with	gene	1.00
cytosolic calcium elevation	activates	mechanism	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in vesicles independe

neurodegeneration | 2026-04-11 | 0 hypotheses

Does tau aggregation specifically cause PS externalization in living cells versu

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate identified a critical gap in understanding whether PS exposure is tau

closed · Rounds: 4 · Score: 0.44 · 2026-04-21

The debate revealed a fundamental gap in understanding whether tau pathology dir

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TMEM16F in their description or question text

No additional research found