Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB27A/LAMP2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | RAB27A/LAMP2B |
| Key Genes/Proteins | ChR2, GJA1, PANX1, PARKIN, PINK1, RAB27A |
| Related Diseases | neurodegeneration |
graph TD
RAB27A_LAMP2B[RAB27A/LAMP2B]
RAB27A_LAMP2B -->|debate_co_mention| RHOT1[RHOT1]
RAB27A_LAMP2B -->|debate_co_mention| Synthetic_fusion_proteins[Synthetic fusion proteins]
RAB27A_LAMP2B -->|implicated in| neurodegeneration[neurodegeneration]
h_d78123d1[h-d78123d1] -->|targets| RAB27A_LAMP2B
PANX1[PANX1] -->|debate_co_mention| RAB27A_LAMP2B
PARKIN[PARKIN] -->|debate_co_mention| RAB27A_LAMP2B
PINK1[PINK1] -->|debate_co_mention| RAB27A_LAMP2B
RAB27A[RAB27A] -->|debate_co_mention| RAB27A_LAMP2B
ChR2[ChR2] -->|co_associated_with| RAB27A_LAMP2B
GJA1[GJA1] -->|co_associated_with| RAB27A_LAMP2B| Target | Relation | Type | Str |
|---|---|---|---|
| RHOT1 | debate_co_mention | gene | 0.45 |
| Synthetic fusion proteins | debate_co_mention | gene | 0.45 |
| RHOT1 | co_associated_with | gene | 0.40 |
| Synthetic fusion proteins | co_associated_with | gene | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglia-Derived Extracellular Vesicle Engineering for Targ | 0.482 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-res [PMID:41787360] | ["Xiang S", "Qin T", "Qin Y", "Sun Y", " | Journal of nanobiotechnology | 2026 | 0 |
| hUC-MSC-derived exosomes ameliorate Alzheimer's disease pathology through lncRNA [PMID:41540476] | Zhang Y, Zhang F, Yin H, Sun Y, Wang Y, | Alzheimer's research & therapy | 2026 | 0 |
| Engineered Biomimetic Nanorobots Orchestrate Targeted Nose-to-Brain Delivery to [PMID:41607240] | ["Xu Y", "Zhao J", "Xu X", "Liu Y", "Li | Small (Weinheim an der Bergstr | 2026 | 0 |
| Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA f [PMID:41749221] | ["Shie M", "Chiu C", "Chen Y", "Lin Y", | Journal of nanobiotechnology | 2026 | 0 |
| Extracellular vesicles: A new therapeutic drug for nerve injury repair. [PMID:41467441] | ["Cai J", "Ren C", "Wang C", "Shen S", " | Neural regeneration research | 2025 | 0 |
| Engineered extracellular vesicles-mediated curcumin delivery in brain microenvir [PMID:41390406] | ["Shie M", "Chen M", "Chen Y", "Huang S" | Journal of nanobiotechnology | 2025 | 0 |
| Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to co [PMID:37529842] | Sun Q, Weng RX, Li JH, Li YC, Xu JT, Li | American journal of physiology | 2023 | 0 |
| Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles [PMID:33282910] | van Solinge TS, Abels ER, van de Haar LL | Frontiers in molecular bioscie | 2020 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
| Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome. [PMID:31261156] | Presta V, Miceli F, Tocci G | Cardiology | 2019 | 0 |
| Metformin use and risk of gastric adenocarcinoma in a Swedish population-based c [PMID:31591459] | Zheng J, Xie SH, Santoni G, Lagergren J | British journal of cancer | 2019 | 0 |
| Aiming for the target: Mitochondrial drug delivery in traumatic brain injury. [PMID:30009835] | Lamade AM, Kenny EM, Anthonymuthu TS, So | Neuropharmacology | 2019 | 0 |
| A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illumina [PMID:30816224] | Neckles VN, Morton MC, Holmberg JC, Soko | Scientific reports | 2019 | 0 |
| The Science and Translation of Lactate Shuttle Theory. [PMID:29617642] | Brooks GA | Cell metabolism | 2018 | 0 |
| Brain Photobiomodulation Therapy: a Narrative Review. [PMID:29327206] | ["Salehpour F", "Mahmoudi J", "Kamari F" | Molecular neurobiology | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.71 · 2026-04-12
closed · Rounds: 4 · Score: 0.81 · 2026-04-06
Hypotheses and analyses mentioning RAB27A/LAMP2B in their description or question text
No additional research found