| Gene Symbol | SIRPA |
| Aliases | SIRPAPROTEIN |
| Chromosome | 20q13.13 |
| Function | SIRPA (Signal Regulatory Protein Alpha) is a transmembrane protein that primarily expressed on macrophages, dendritic cells, and neurons. |
| Primary Expression | neurons, may regulate synaptic function |
| Amino Acids | 504 aa |
| Pathways | Complement |
| Ensembl ID | ENSG00000198053 |
| GeneCards | SIRPA |
| Human Protein Atlas | SIRPA |
| CD47 | Primary SIRPA ligand mediating "don't eat me" signals |
| SHP-2 | Phosphatase recruited by SIRPA ITIMs |
| Microglia | Primary SIRPA-expressing cells in the brain |
| Thrombospondin-1 | Alternative SIRPA ligand |
| Complement system | Interacting pathway in synaptic pruning |
| Associated Diseases | Aging, Alzheimer, Senescence |
| Interactions | ALZHEIMER, C1QA, C1QB, C1QC, C1R, C1S |
| KG Connections | 107 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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